7,8-dimethoxy-(10,11-dihydro-5H-pyrrolo[2,1-c][1,4] benzodiazepin-10-yl)-(4-bromo-3-methyl-phenyl)-methanone

Base Information

• Chemical Name: 7,8-dimethoxy-(10,11-dihydro-5H-pyrrolo[2,1-c][1,4] benzodiazepin-10-yl)-(4-bromo-3-methyl-phenyl)-methanone
• CAS No.: 473264-11-8
• Molecular Formula: C₂₂H₂₁BrN₂O₃
• Molecular Weight: 441.324

Synonyms:7,8-dimethoxy-(10,11-dihydro-5H-pyrrolo[2,1-c][1,4] benzodiazepin-10-yl)-(4-bromo-3-methyl-phenyl)-methanone

Chemical Property of 7,8-dimethoxy-(10,11-dihydro-5H-pyrrolo[2,1-c][1,4] benzodiazepin-10-yl)-(4-bromo-3-methyl-phenyl)-methanone

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Technology Process of 7,8-dimethoxy-(10,11-dihydro-5H-pyrrolo[2,1-c][1,4] benzodiazepin-10-yl)-(4-bromo-3-methyl-phenyl)-methanone

There total 2 articles about 7,8-dimethoxy-(10,11-dihydro-5H-pyrrolo[2,1-c][1,4] benzodiazepin-10-yl)-(4-bromo-3-methyl-phenyl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-3-methylbenzoyl chloride (21900-25-4) + 7,8-dimethoxy-10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine (53478-80-1) → 7,8-dimethoxy-(10,11-dihydro-5H-pyrrolo[2,1-c][1,4] benzodiazepin-10-yl)-(4-bromo-3-methyl-phenyl)-methanone (473264-11-8)

Guidance literature:

With triethylamine; In dichloromethane; ethyl acetate; Petroleum ether;

Reference yield:

7,8-Dimethoxy 10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine + 7,8-dimethoxy-10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine (53478-80-1) + 3-Methylbenzoyl chloride (1711-06-4) → 7,8-dimethoxy-(10,11-dihydro-5H-pyrrolo[2,1-c][1,4] benzodiazepin-10-yl)-(4-bromo-3-methyl-phenyl)-methanone (473264-11-8)

Guidance literature:

With triethylamine; In dichloromethane; ethyl acetate; Petroleum ether;

Reference yield:

potassium phosphate + 7,8-dimethoxy-(10,11-dihydro-5H-pyrrolo[2,1-c][1,4] benzodiazepin-10-yl)-(4-bromo-3-methyl-phenyl)-methanone (473264-11-8) + 2-(trifluoromethyl)phenylboronic acid (1423-27-4) → 7,8-dimethoxy-[10,11-dihydro-5H-pyrrolo [2,1-c][1,4]benzodiazepin-10-yl][2-methyl-2'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methanone (473260-62-7)

Guidance literature:

tetrakis(triphenylphosphine)palladium ⁽⁰⁾; In 1,4-dioxane; dichloromethane;

upstream raw materials:

4-bromo-3-methylbenzoyl chloride

7,8-dimethoxy-10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine

3-Methylbenzoyl chloride

Downstream raw materials:

7,8-dimethoxy-[10,11-dihydro-5H-pyrrolo [2,1-c][1,4]benzodiazepin-10-yl][2-methyl-2'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methanone

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