1 2:5 6-DI-O-ISOPROPYLIDENE-D-MANNITOL

Base Information

• Chemical Name: 1 2:5 6-DI-O-ISOPROPYLIDENE-D-MANNITOL
• CAS No.: 106571-12-4
• Molecular Formula: C₁₂H₂₀O₈S
• Molecular Weight: 324.352
• Mol file: 106571-12-4.mol

Synonyms:D-Mannitol,1,2:5,6-bis-O-(1-methylethylidene)-, cyclic sulfate (9CI); Mannitol,1,2:5,6-di-O-isopropylidene-, cyclic sulfate, D- (7CI); 1,3,2-Dioxathiolane,D-mannitol deriv.; 1,2:5,6-Di-o-isopropylidene-D-mannitol cyclic sulfate

Chemical Property of 1 2:5 6-DI-O-ISOPROPYLIDENE-D-MANNITOL

Chemical Property:

• Melting Point: 126-128 °C(lit.)
• PSA: 97.90000
• LogP: 1.39900

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1 2:5 6-DI-O-ISOPROPYLIDENE-D-MANNITOL

There total 3 articles about 1 2:5 6-DI-O-ISOPROPYLIDENE-D-MANNITOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Schwefligsaeure-(1,2;5,6-di-O-isopropylidendioxy-D-manno-hexan-3,4-diylester) (95980-28-2) → D-mannitol 1,2:5,6-diacetonide 2,3-cyclic sulfate (106571-12-4)

Guidance literature:

With sodium periodate; ruthenium trichloride; In tetrachloromethane; water; acetonitrile; at 0 ℃; for 0.75h; Yield given;

DOI:10.1016/S0040-4039(01)80274-4

Reference yield:

1,2:5,6-di-O-isopropylidene-D-mannitol (1707-77-3) → D-mannitol 1,2:5,6-diacetonide 2,3-cyclic sulfate (106571-12-4)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂, NEt₃ / CH₂Cl₂ / 0.25 h / 0 °C

2: NaIO₄ / RuCl₃*H₂O / CCl₄; acetonitrile; H₂O / 0.75 h / 0 °C

With sodium periodate; thionyl chloride; triethylamine; ruthenium trichloride; In tetrachloromethane; dichloromethane; water; acetonitrile;

DOI:10.1016/S0040-4039(01)80274-4

Reference yield:

→ D-mannitol 1,2:5,6-diacetonide 2,3-cyclic sulfate (106571-12-4)

Guidance literature:

aus 1,2;5,6-Di-O-isopropyliden-D-mannit-3,4-cyclosulfit in Eisessig, wss. Calcium-permanganat;

upstream raw materials:

Schwefligsaeure-(1,2;5,6-di-O-isopropylidendioxy-D-manno-hexan-3,4-diylester)

1,2:5,6-di-O-isopropylidene-D-mannitol

Downstream raw materials:

3-amino-3-deoxy-1,2:5,6-di-O-isopropylidene-D-altritol