2-(5-methoxy-4′-methyl[1,1′-biphenyl]-2-yl)-4,4-dimethyl-4,5-dihydrooxazole

Base Information

Chemical Name:2-(5-methoxy-4′-methyl[1,1′-biphenyl]-2-yl)-4,4-dimethyl-4,5-dihydrooxazole
CAS No.:149554-44-9
Molecular Formula:C₁₉H₂₁NO₂
Molecular Weight:295.381
Hs Code.:

Synonyms:2-(5-methoxy-4′-methyl[1,1′-biphenyl]-2-yl)-4,4-dimethyl-4,5-dihydrooxazole

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Chemical Property of 2-(5-methoxy-4′-methyl[1,1′-biphenyl]-2-yl)-4,4-dimethyl-4,5-dihydrooxazole

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Technology Process of 2-(5-methoxy-4′-methyl[1,1′-biphenyl]-2-yl)-4,4-dimethyl-4,5-dihydrooxazole

There total 5 articles about 2-(5-methoxy-4′-methyl[1,1′-biphenyl]-2-yl)-4,4-dimethyl-4,5-dihydrooxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: C₁₃H₂₂O₃Ti

: 4,4-dimethyl-2-(2-iodo-4-methoxyphenyl)-2-oxazoline

: 149554-44-9
2-(5-methoxy-4′-methyl[1,1′-biphenyl]-2-yl)-4,4-dimethyl-4,5-dihydrooxazole

Guidance literature:: C₁₃H₂₂O₃Ti; 4,4-dimethyl-2-(2-iodo-4-methoxyphenyl)-2-oxazoline; With TurboGrignard; In tetrahydrofuran; at -40 - 0 ℃; for 2.66667h; Inert atmosphere;

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; oxygen; cobalt(II) chloride; In tetrahydrofuran; at 0 ℃; Reagent/catalyst; Temperature;
DOI:10.1021/acs.joc.5b01787

Reference yield:

: 4294-57-9
para-methylphenylmagnesium bromide

: 149554-44-9
2-(5-methoxy-4′-methyl[1,1′-biphenyl]-2-yl)-4,4-dimethyl-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2.1: TurboGrignard / tetrahydrofuran / 2.67 h / -40 - 0 °C / Inert atmosphere

2.2: 0 °C

With TurboGrignard; In tetrahydrofuran;
DOI:10.1021/acs.joc.5b01787