3-Amino-2-(2-chlorophenyl)propan-1-ol

Base Information

• Chemical Name: 3-Amino-2-(2-chlorophenyl)propan-1-ol
• CAS No.: 21464-47-1
• Molecular Formula: C₉H₁₂ClNO
• Molecular Weight: 185.653
• ChEMBL ID: CHEMBL4527962
• DSSTox Substance ID: DTXSID101283036

Synonyms:3-amino-2-(2-chlorophenyl)propan-1-ol;21464-47-1;SCHEMBL167010;CHEMBL4527962;GEOBVXBWIQAFSR-UHFFFAOYSA-N;DTXSID101283036;AKOS017530377;I(2)-(Aminomethyl)-2-chlorobenzeneethanol;EN300-208751

Chemical Property of 3-Amino-2-(2-chlorophenyl)propan-1-ol

Chemical Property:

• XLogP3: 1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 185.0607417
• Heavy Atom Count: 12
• Complexity: 132

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(CN)CO)Cl

Technology Process of 3-Amino-2-(2-chlorophenyl)propan-1-ol

There total 3 articles about 3-Amino-2-(2-chlorophenyl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Chlorophenylacetonitrile (2856-63-5) → 3-amino-2-(2-chlorophenyl)propan-1-ol (21464-47-1)

Guidance literature:

Multi-step reaction with 3 steps

1: NaOEt

2: H₂, H₂SO₄ / PtO₂ / acetic acid / 37510.9 Torr / Ambient temperature

3: LiAlH₄ / diethyl ether / Heating

With lithium aluminium tetrahydride; sulfuric acid; hydrogen; sodium ethanolate; platinum(IV) oxide; In diethyl ether; acetic acid;

DOI:10.1002/ardp.19683011006

Reference yield:

(+/-)-ethyl (2-chlorophenyl)(cyano)acetate (4383-51-1) → 3-amino-2-(2-chlorophenyl)propan-1-ol (21464-47-1)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂, H₂SO₄ / PtO₂ / acetic acid / 37510.9 Torr / Ambient temperature

2: LiAlH₄ / diethyl ether / Heating

With lithium aluminium tetrahydride; sulfuric acid; hydrogen; platinum(IV) oxide; In diethyl ether; acetic acid;

DOI:10.1002/ardp.19683011006

Reference yield:

(+/-)-ethyl 3-amino-2-(2-chlorophenyl)propanoate (4251-58-5) → 3-amino-2-(2-chlorophenyl)propan-1-ol (21464-47-1)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; Heating;

DOI:10.1002/ardp.19683011006

upstream raw materials:

(+/-)-ethyl 3-amino-2-(2-chlorophenyl)propanoate

2-Chlorophenylacetonitrile

(+/-)-ethyl (2-chlorophenyl)(cyano)acetate

Downstream raw materials:

2-(2-chlorophenyl)-3-[({3-(4-chlorophenyl)-5-oxo-4-[(1E)-3,3,3-trifluoroprop-1-en-1-yl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]propyl carbamate

2-(2-chlorophenyl)-3-[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]propyl carbamate

2-(2-chlorophenyl)-3-[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]propyl carbamate

3-amino-2-(2-chlorophenyl)propyl carbamate

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