(1S,4R)-4,7,7-Trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid (2S,3R)-7-methoxy-2-(3-methoxy-4-methoxymethoxy-phenyl)-5-((E)-3-oxo-propenyl)-2,3-dihydro-benzofuran-3-ylmethyl ester

Base Information

• Chemical Name: (1S,4R)-4,7,7-Trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid (2S,3R)-7-methoxy-2-(3-methoxy-4-methoxymethoxy-phenyl)-5-((E)-3-oxo-propenyl)-2,3-dihydro-benzofuran-3-ylmethyl ester
• CAS No.: 215227-86-4
• Molecular Formula: C₃₂H₃₆O₁₀
• Molecular Weight: 580.632

Synonyms:(1S,4R)-4,7,7-Trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid (2S,3R)-7-methoxy-2-(3-methoxy-4-methoxymethoxy-phenyl)-5-((E)-3-oxo-propenyl)-2,3-dihydro-benzofuran-3-ylmethyl ester

Chemical Property of (1S,4R)-4,7,7-Trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid (2S,3R)-7-methoxy-2-(3-methoxy-4-methoxymethoxy-phenyl)-5-((E)-3-oxo-propenyl)-2,3-dihydro-benzofuran-3-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1S,4R)-4,7,7-Trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid (2S,3R)-7-methoxy-2-(3-methoxy-4-methoxymethoxy-phenyl)-5-((E)-3-oxo-propenyl)-2,3-dihydro-benzofuran-3-ylmethyl ester

There total 1 articles about (1S,4R)-4,7,7-Trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid (2S,3R)-7-methoxy-2-(3-methoxy-4-methoxymethoxy-phenyl)-5-((E)-3-oxo-propenyl)-2,3-dihydro-benzofuran-3-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1S)-(-)-camphanic chloride (39637-74-6) + (E)-3-[(2R*,3S*)-2,3-dihydro-3-hydroxymethyl-7-methoxy-2-(3-methoxy-4-methoxymethoxyphenyl)-1-benzofuran-5-yl]-2-propenal (118799-85-2) → (1S,4R)-4,7,7-Trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid (2S,3R)-7-methoxy-2-(3-methoxy-4-methoxymethoxy-phenyl)-5-((E)-3-oxo-propenyl)-2,3-dihydro-benzofuran-3-ylmethyl ester (215227-86-4) + (1S,4R)-4,7,7-Trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid (2R,3S)-7-methoxy-2-(3-methoxy-4-methoxymethoxy-phenyl)-5-((E)-3-oxo-propenyl)-2,3-dihydro-benzofuran-3-ylmethyl ester (215228-23-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 3h; Ambient temperature;

DOI:10.1016/S0040-4020(98)00725-X

Reference yield: 88.0%

(1S,4R)-4,7,7-Trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid (2S,3R)-7-methoxy-2-(3-methoxy-4-methoxymethoxy-phenyl)-5-((E)-3-oxo-propenyl)-2,3-dihydro-benzofuran-3-ylmethyl ester (215227-86-4) → (E)-3-[(2S,3R)-2,3-dihydro-3-hydroxymethyl-7-methoxy-2-(3'-methoxy-4'-methoxymethoxyphenyl)-1-benzo[b]furan-5-yl]-2-propenal (215227-96-6)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; methanol; for 0.5h;

DOI:10.1016/S0040-4020(98)00725-X

Reference yield: 85.5%

(1S,4R)-4,7,7-Trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid (2S,3R)-7-methoxy-2-(3-methoxy-4-methoxymethoxy-phenyl)-5-((E)-3-oxo-propenyl)-2,3-dihydro-benzofuran-3-ylmethyl ester (215227-86-4) → (1S,4R)-4,7,7-Trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid (2S,3R)-2-(4-hydroxy-3-methoxy-phenyl)-7-methoxy-5-((E)-3-oxo-propenyl)-2,3-dihydro-benzofuran-3-ylmethyl ester (215227-91-1)

Guidance literature:

With hydrogenchloride; In methanol; for 2h;

DOI:10.1016/S0040-4020(98)00725-X

upstream raw materials:

(1S)-(-)-camphanic chloride

(E)-3-[(2R*,3S*)-2,3-dihydro-3-hydroxymethyl-7-methoxy-2-(3-methoxy-4-methoxymethoxyphenyl)-1-benzofuran-5-yl]-2-propenal

Downstream raw materials:

(E)-3-[(2S,3R)-2,3-dihydro-3-hydroxymethyl-7-methoxy-2-(3'-methoxy-4'-methoxymethoxyphenyl)-1-benzo[b]furan-5-yl]-2-propenal

(1S,4R)-4,7,7-Trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid (2S,3R)-2-(4-hydroxy-3-methoxy-phenyl)-7-methoxy-5-((E)-3-oxo-propenyl)-2,3-dihydro-benzofuran-3-ylmethyl ester

(2S,3R)-2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-5-[(E)-3-hydroxy-1-propenyl]-3-hydroxymethyl-7-methoxybenzo[b]furan

(E)-3-[(2S,3R)-2,3-dihydro-2-(4'-hydroxy-3'-methoxyphenyl)-3-hydroxymethyl-7-methoxy-1-benzo[b]furan-5-yl]-2-propenal

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