4-[4-hydroxymethyl-4-(4-hydroxyphenyl)-3-methyl-2,5-dioxo-imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

Base Information

Chemical Name:4-[4-hydroxymethyl-4-(4-hydroxyphenyl)-3-methyl-2,5-dioxo-imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile
CAS No.:959692-07-0
Molecular Formula:C₁₉H₁₄F₃N₃O₄
Molecular Weight:405.333
Hs Code.:

Synonyms:4-[4-hydroxymethyl-4-(4-hydroxyphenyl)-3-methyl-2,5-dioxo-imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[4-hydroxymethyl-4-(4-hydroxyphenyl)-3-methyl-2,5-dioxo-imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 4-[4-hydroxymethyl-4-(4-hydroxyphenyl)-3-methyl-2,5-dioxo-imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

There total 5 articles about 4-[4-hydroxymethyl-4-(4-hydroxyphenyl)-3-methyl-2,5-dioxo-imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 959692-23-0
4-[1-(4-cyano-3-trifluoromethylphenyl)-2,5-dioxo-4-hydroxymethyl-3-methylimidazolidin-4-yl]phenyl 1,1-dimethylethyl carbonate

: 959692-07-0
4-[4-hydroxymethyl-4-(4-hydroxyphenyl)-3-methyl-2,5-dioxo-imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 18h;

Reference yield: 87.0%

: 959691-92-0
4-[4-allyloxymethyl-4-(4-methoxyphenyl)-3-methyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

: 959692-07-0
4-[4-hydroxymethyl-4-(4-hydroxyphenyl)-3-methyl-2,5-dioxo-imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

Guidance literature:: With boron dimethyl-trifluoro sulphide; In dichloromethane; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1021/jm300281x

Reference yield:

: 191165-13-6
4-bromo-2-(trifluoromethyl)benzonitrile

: 959692-07-0
4-[4-hydroxymethyl-4-(4-hydroxyphenyl)-3-methyl-2,5-dioxo-imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: copper(I) oxide / N,N-dimethyl acetamide / 18 h / 160 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

3: boron dimethyl-trifluoro sulphide / dichloromethane / 18 h / 20 °C / Inert atmosphere

With copper(I) oxide; boron dimethyl-trifluoro sulphide; potassium carbonate; In dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/jm300281x