(1S,3R,6S)-2-(hydroxymethyl)-(Z)-9-(3,4-dichlorophenylmethylene)-7-azatricyclo[4.3.1.0^3,7]decane

Base Information

• Chemical Name: (1S,3R,6S)-2-(hydroxymethyl)-(Z)-9-(3,4-dichlorophenylmethylene)-7-azatricyclo[4.3.1.0^3,7]decane
• CAS No.: 275355-64-1
• Molecular Formula: C₁₇H₁₉Cl₂NO
• Molecular Weight: 324.25

Synonyms:(1S,3R,6S)-2-(hydroxymethyl)-(Z)-9-(3,4-dichlorophenylmethylene)-7-azatricyclo[4.3.1.0^3,7]decane

Chemical Property of (1S,3R,6S)-2-(hydroxymethyl)-(Z)-9-(3,4-dichlorophenylmethylene)-7-azatricyclo[4.3.1.0^3,7]decane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,3R,6S)-2-(hydroxymethyl)-(Z)-9-(3,4-dichlorophenylmethylene)-7-azatricyclo[4.3.1.0^3,7]decane

There total 3 articles about (1S,3R,6S)-2-(hydroxymethyl)-(Z)-9-(3,4-dichlorophenylmethylene)-7-azatricyclo[4.3.1.0^3,7]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(1S,3R,6S)-(Z)-9-(3,4-dichlorophenylmethylene)-7-azatricyclo[4.3.1.03,7]decane-2β-carboxylic acid methyl ester (275355-56-1) → (1S,3R,6S)-2-(hydroxymethyl)-(Z)-9-(3,4-dichlorophenylmethylene)-7-azatricyclo[4.3.1.03,7]decane (275355-64-1)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; for 3h;

DOI:10.1021/jm0001121

Reference yield:

3,4-dichloroiodobenzene (20555-91-3) → (1S,3R,6S)-2-(hydroxymethyl)-(Z)-9-(3,4-dichlorophenylmethylene)-7-azatricyclo[4.3.1.03,7]decane (275355-64-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / tris(o-tolyl)phosphine; Pd₂(dba)3; CuI / dimethylformamide / 12 h / 45 - 50 °C

2: 89 percent / DIBAL-H / tetrahydrofuran / 3 h

With copper(l) iodide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; diisobutylaluminium hydride; tris-(o-tolyl)phosphine; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Arylation / 2: Reduction;

DOI:10.1021/jm0001121

Reference yield:

(1S,3R,6S)-(Z)-9-[(tri-n-butylstannyl)methylene]-7-azatricyclo[4.3.1.03,7]decane-2β-carboxylic acid methyl ester (275355-50-5,275355-51-6) → (1S,3R,6S)-2-(hydroxymethyl)-(Z)-9-(3,4-dichlorophenylmethylene)-7-azatricyclo[4.3.1.03,7]decane (275355-64-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / tris(o-tolyl)phosphine; Pd₂(dba)3; CuI / dimethylformamide / 12 h / 45 - 50 °C

2: 89 percent / DIBAL-H / tetrahydrofuran / 3 h

With copper(l) iodide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; diisobutylaluminium hydride; tris-(o-tolyl)phosphine; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Arylation / 2: Reduction;

DOI:10.1021/jm0001121

upstream raw materials:

(1S,3R,6S)-(Z)-9-(3,4-dichlorophenylmethylene)-7-azatricyclo[4.3.1.0^3,7]decane-2β-carboxylic acid methyl ester

3,4-dichloroiodobenzene

(1S,3R,6S)-(Z)-9-[(tri-n-butylstannyl)methylene]-7-azatricyclo[4.3.1.0^3,7]decane-2β-carboxylic acid methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 275355-64-1 (1S,3R,6S)-2-(hydroxymethyl)-(Z)-9-(3,4-dichlorophenylmethylene)-7-azatricyclo[4.3.1.0^3,7]decane

Send

Send

Metric Ton KG G Pound L ML

Send

Send