(4R,1'R)-1-phenylethyl-4-tetrahydropyranyloxymethylpyrrolidin-2-one

Base Information

• Chemical Name: (4R,1'R)-1-phenylethyl-4-tetrahydropyranyloxymethylpyrrolidin-2-one
• CAS No.: 637014-19-8
• Molecular Formula: C₁₈H₂₅NO₃
• Molecular Weight: 303.401
• Mol file: 637014-19-8.mol

Synonyms:(4R,1'R)-1-phenylethyl-4-tetrahydropyranyloxymethylpyrrolidin-2-one

Chemical Property of (4R,1'R)-1-phenylethyl-4-tetrahydropyranyloxymethylpyrrolidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

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Technology Process of (4R,1'R)-1-phenylethyl-4-tetrahydropyranyloxymethylpyrrolidin-2-one

There total 1 articles about (4R,1'R)-1-phenylethyl-4-tetrahydropyranyloxymethylpyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

3,4-dihydro-2H-pyran (110-87-2) + (4R,1'R)-1-(1'-phenylethyl)-4-hydroxymethylpyrrolidin-2-one (190957-22-3) → (4R,1'R)-1-phenylethyl-4-tetrahydropyranyloxymethylpyrrolidin-2-one (637014-19-8)

Guidance literature:

With resin 15; In ethyl acetate; at 0 ℃; for 3h;

DOI:10.3987/com-03-9854

Reference yield: 71.0%

Benzyloxymethyl chloride (3587-60-8) + (4R,1'R)-1-phenylethyl-4-tetrahydropyranyloxymethylpyrrolidin-2-one (637014-19-8) → (3R,4R,1'R)-3-benzyloxymethyl-1-phenylethyl-4-tetrahydropyranyloxymethylpyrrolidin-2-one

Guidance literature:

(4R,1'R)-1-phenylethyl-4-tetrahydropyranyloxymethylpyrrolidin-2-one; With n-butyllithium; In tetrahydrofuran; hexane; at -15 ℃; for 0.333333h;

Benzyloxymethyl chloride; In tetrahydrofuran; hexane; at -15 ℃; for 2h;

DOI:10.3987/com-03-9854

Reference yield: 68.0%

methyl chloroformate (79-22-1) + (4R,1'R)-1-phenylethyl-4-tetrahydropyranyloxymethylpyrrolidin-2-one (637014-19-8) → (3R,4R,1'R)-3-methoxycarbonyl-1-phenylethyl-4-tetrahydropyranyloxymethylpyrrolidin-2-one

Guidance literature:

(4R,1'R)-1-phenylethyl-4-tetrahydropyranyloxymethylpyrrolidin-2-one; With n-butyllithium; In tetrahydrofuran; hexane; at -15 ℃; for 0.333333h;

methyl chloroformate; In tetrahydrofuran; hexane; at -15 ℃; for 2h;

DOI:10.3987/com-03-9854

upstream raw materials:

3,4-dihydro-2H-pyran

(4R,1'R)-1-(1'-phenylethyl)-4-hydroxymethylpyrrolidin-2-one