5'-[5-(4-bromo-benzyl)-3-(4-fluoro-benzyl)-1H-pyrrol-2-ylmethylene]-4'-methoxy-1H,5'H-[2,2']bipyrrolyl

Base Information

• Chemical Name: 5'-[5-(4-bromo-benzyl)-3-(4-fluoro-benzyl)-1H-pyrrol-2-ylmethylene]-4'-methoxy-1H,5'H-[2,2']bipyrrolyl
• CAS No.: 1314252-83-9
• Molecular Formula: C₂₈H₂₃BrFN₃O
• Molecular Weight: 516.413

Synonyms:5'-[5-(4-bromo-benzyl)-3-(4-fluoro-benzyl)-1H-pyrrol-2-ylmethylene]-4'-methoxy-1H,5'H-[2,2']bipyrrolyl

Chemical Property of 5'-[5-(4-bromo-benzyl)-3-(4-fluoro-benzyl)-1H-pyrrol-2-ylmethylene]-4'-methoxy-1H,5'H-[2,2']bipyrrolyl

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Technology Process of 5'-[5-(4-bromo-benzyl)-3-(4-fluoro-benzyl)-1H-pyrrol-2-ylmethylene]-4'-methoxy-1H,5'H-[2,2']bipyrrolyl

There total 5 articles about 5'-[5-(4-bromo-benzyl)-3-(4-fluoro-benzyl)-1H-pyrrol-2-ylmethylene]-4'-methoxy-1H,5'H-[2,2']bipyrrolyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

C18H15BrFN (1314253-73-0) + 4-methoxy-2,2'-bipyrrole-5-carboxaldehyde (10476-41-2) → 5'-[5-(4-bromo-benzyl)-3-(4-fluoro-benzyl)-1H-pyrrol-2-ylmethylene]-4'-methoxy-1H,5'H-[2,2']bipyrrolyl (1314252-83-9)

Guidance literature:

With hydrogenchloride; In methanol; at 25 ℃; for 5h; Inert atmosphere;

DOI:10.1021/jm200543y

Reference yield:

N-((5-bromo-3-methoxy-2H-pyrrol-2-ylidene)-methyl)-N-ethylethanamine (803712-71-2) → 5'-[5-(4-bromo-benzyl)-3-(4-fluoro-benzyl)-1H-pyrrol-2-ylmethylene]-4'-methoxy-1H,5'H-[2,2']bipyrrolyl (1314252-83-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: palladium diacetate; triphenylphosphine / 1,4-dioxane; water; toluene / 70 °C / Inert atmosphere

1.2: 3 h / 100 °C / Inert atmosphere

2.1: hydrogenchloride; water / pH 7 / Inert atmosphere

3.1: hydrogenchloride / methanol / 5 h / 25 °C / Inert atmosphere

With hydrogenchloride; water; palladium diacetate; triphenylphosphine; In 1,4-dioxane; methanol; water; toluene;

DOI:10.1021/jm200543y

Reference yield:

C14H16N2O4 → 5'-[5-(4-bromo-benzyl)-3-(4-fluoro-benzyl)-1H-pyrrol-2-ylmethylene]-4'-methoxy-1H,5'H-[2,2']bipyrrolyl (1314252-83-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; water / pH 7 / Inert atmosphere

2: hydrogenchloride / methanol / 5 h / 25 °C / Inert atmosphere

With hydrogenchloride; water; In methanol;

DOI:10.1021/jm200543y

upstream raw materials:

N-((5-bromo-3-methoxy-2H-pyrrol-2-ylidene)-methyl)-N-ethylethanamine

C₁₈H₁₅BrFN

4-methoxy-2,2'-bipyrrole-5-carboxaldehyde

C₁₈H₁₁BrFNO₂

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