5-((4-(benzyloxy)benzyl)(4H-1,2,4-triazol-4-yl)amino)biphenyl-2,4'-dicarbonitrile

Base Information

Chemical Name:5-((4-(benzyloxy)benzyl)(4H-1,2,4-triazol-4-yl)amino)biphenyl-2,4'-dicarbonitrile
CAS No.:1260389-66-9
Molecular Formula:C₃₀H₂₂N₆O
Molecular Weight:482.544
Hs Code.:

Synonyms:5-((4-(benzyloxy)benzyl)(4H-1,2,4-triazol-4-yl)amino)biphenyl-2,4'-dicarbonitrile

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Chemical Property of 5-((4-(benzyloxy)benzyl)(4H-1,2,4-triazol-4-yl)amino)biphenyl-2,4'-dicarbonitrile

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Technology Process of 5-((4-(benzyloxy)benzyl)(4H-1,2,4-triazol-4-yl)amino)biphenyl-2,4'-dicarbonitrile

There total 3 articles about 5-((4-(benzyloxy)benzyl)(4H-1,2,4-triazol-4-yl)amino)biphenyl-2,4'-dicarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1260389-63-6
4-((4-(benzyloxy)benzyl)(4H-1,2,4-triazol-4-yl)amino)-2-bromo-benzonitrile

: 126747-14-6
4-cyanophenylboronic acid

: 1260389-66-9
5-((4-(benzyloxy)benzyl)(4H-1,2,4-triazol-4-yl)amino)biphenyl-2,4'-dicarbonitrile

Guidance literature:: With sodium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; for 5h; Heating; Reflux;

Reference yield:

: 36282-26-5
2-bromo-4-fluorobenzonitrile

: 1260389-66-9
5-((4-(benzyloxy)benzyl)(4H-1,2,4-triazol-4-yl)amino)biphenyl-2,4'-dicarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 0.5 h / 20 °C

1.2: 1 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

2.2: 18 h / 20 °C

3.1: sodium carbonate / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 5 h / Heating; Reflux

With potassium tert-butylate; sodium hydride; sodium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1260389-62-5
4-(4H-1,2,4-triazol-4-ylamino)-2-bromo-benzonitrile

: 1260389-66-9
5-((4-(benzyloxy)benzyl)(4H-1,2,4-triazol-4-yl)amino)biphenyl-2,4'-dicarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

1.2: 18 h / 20 °C

2.1: sodium carbonate / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 5 h / Heating; Reflux

With sodium hydride; sodium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; mineral oil;