(S)-diphenyl-N-(pyrrolidin-2-ylmethyl)phosphinamide

Base Information

• Chemical Name: (S)-diphenyl-N-(pyrrolidin-2-ylmethyl)phosphinamide
• CAS No.: 1206881-78-8
• Molecular Formula: C₁₇H₂₁N₂OP
• Molecular Weight: 300.34
• Mol file: 1206881-78-8.mol

Synonyms:(S)-diphenyl-N-(pyrrolidin-2-ylmethyl)phosphinamide

Chemical Property of (S)-diphenyl-N-(pyrrolidin-2-ylmethyl)phosphinamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (S)-diphenyl-N-(pyrrolidin-2-ylmethyl)phosphinamide

There total 2 articles about (S)-diphenyl-N-(pyrrolidin-2-ylmethyl)phosphinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

(S)-tert-butyl 2-((N,N-diphenylphosphinamido)methyl)pyrrolidine-1-carboxylate (1206881-77-7) → (S)-diphenyl-N-(pyrrolidin-2-ylmethyl)phosphinamide (1206881-78-8)

Guidance literature:

With chlorotriisopropylsilane; trifluoroacetic acid; In dimethylsulfide; dichloromethane; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.tetlet.2009.10.131

Reference yield: 9.0%

(S)-benzyl 2-((N,N-diphenylphosphinamido)methyl)pyrrolidine-1-carboxylate (1206881-76-6) → (S)-diphenyl-N-(pyrrolidin-2-ylmethyl)phosphinamide (1206881-78-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; cyclohexane; for 3h; Inert atmosphere; Reflux;

DOI:10.1016/j.tetlet.2009.10.131

upstream raw materials:

(S)-tert-butyl 2-((N,N-diphenylphosphinamido)methyl)pyrrolidine-1-carboxylate

(S)-benzyl 2-((N,N-diphenylphosphinamido)methyl)pyrrolidine-1-carboxylate