(R)-tert-butyl 6-(2-((2-(3-amino-4-fluorophenyl)-2-hydroxyethyl)(tert-butoxycarbonyl)amino)ethoxy)-3-chloroindazole-1-carboxylate

Base Information

• Chemical Name: (R)-tert-butyl 6-(2-((2-(3-amino-4-fluorophenyl)-2-hydroxyethyl)(tert-butoxycarbonyl)amino)ethoxy)-3-chloroindazole-1-carboxylate
• CAS No.: 1221235-87-5
• Molecular Formula: C₂₇H₃₄ClFN₄O₆
• Molecular Weight: 565.042
• Mol file: 1221235-87-5.mol

Synonyms:(R)-tert-butyl 6-(2-((2-(3-amino-4-fluorophenyl)-2-hydroxyethyl)(tert-butoxycarbonyl)amino)ethoxy)-3-chloroindazole-1-carboxylate

Chemical Property of (R)-tert-butyl 6-(2-((2-(3-amino-4-fluorophenyl)-2-hydroxyethyl)(tert-butoxycarbonyl)amino)ethoxy)-3-chloroindazole-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-tert-butyl 6-(2-((2-(3-amino-4-fluorophenyl)-2-hydroxyethyl)(tert-butoxycarbonyl)amino)ethoxy)-3-chloroindazole-1-carboxylate

There total 5 articles about (R)-tert-butyl 6-(2-((2-(3-amino-4-fluorophenyl)-2-hydroxyethyl)(tert-butoxycarbonyl)amino)ethoxy)-3-chloroindazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + (R)-tert-butyl 6-(2-(benzyl(2-(4-fluoro-3-nitrophenyl)-2-hydroxyethyl)amino)ethoxy)-3-chloroindazole-1-carboxylate (1221235-86-4) → (R)-tert-butyl 6-(2-((2-(3-amino-4-fluorophenyl)-2-hydroxyethyl)(tert-butoxycarbonyl)amino)ethoxy)-3-chloroindazole-1-carboxylate (1221235-87-5)

Guidance literature:

(R)-tert-butyl 6-(2-(benzyl(2-(4-fluoro-3-nitrophenyl)-2-hydroxyethyl)amino)ethoxy)-3-chloroindazole-1-carboxylate; With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 1h;

With triethylamine; In ethanol;

di-tert-butyl dicarbonate; In methanol; dichloromethane; at 20 ℃;

Reference yield:

tert-butyl 6-((tert-butyldiphenylsilyl)oxy)-3-chloro-1H-indazole-1-carboxylate (1221235-67-1) → (R)-tert-butyl 6-(2-((2-(3-amino-4-fluorophenyl)-2-hydroxyethyl)(tert-butoxycarbonyl)amino)ethoxy)-3-chloroindazole-1-carboxylate (1221235-87-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

2.1: triphenylphosphine; diamide / tetrahydrofuran / 20 °C

3.1: hydrogenchloride; hydrogen / 5%-palladium/activated carbon / ethanol; water; methanol / 1.17 h / 20 °C / Inert atmosphere

4.1: isopropyl alcohol / Reflux

5.1: hydrogenchloride; triethylamine; hydrogen / palladium 10% on activated carbon / ethanol; water / 1 h / 20 °C

5.3: 20 °C

With hydrogenchloride; diamide; tetrabutyl ammonium fluoride; hydrogen; triethylamine; triphenylphosphine; 5%-palladium/activated carbon; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; water; isopropyl alcohol;

Reference yield:

tert-butyl 3-chloro-6-hydroxy-1H-indazole-1-carboxylate (1221235-68-2) → (R)-tert-butyl 6-(2-((2-(3-amino-4-fluorophenyl)-2-hydroxyethyl)(tert-butoxycarbonyl)amino)ethoxy)-3-chloroindazole-1-carboxylate (1221235-87-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: triphenylphosphine; diamide / tetrahydrofuran / 20 °C

2.1: hydrogenchloride; hydrogen / 5%-palladium/activated carbon / ethanol; water; methanol / 1.17 h / 20 °C / Inert atmosphere

3.1: isopropyl alcohol / Reflux

4.1: hydrogenchloride; triethylamine; hydrogen / palladium 10% on activated carbon / ethanol; water / 1 h / 20 °C

4.3: 20 °C

With hydrogenchloride; diamide; hydrogen; triethylamine; triphenylphosphine; 5%-palladium/activated carbon; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; water; isopropyl alcohol;

upstream raw materials:

di-tert-butyl dicarbonate

(R)-tert-butyl 6-(2-(benzyl(2-(4-fluoro-3-nitrophenyl)-2-hydroxyethyl)amino)ethoxy)-3-chloroindazole-1-carboxylate

tert-butyl 6-((tert-butyldiphenylsilyl)oxy)-3-chloro-1H-indazole-1-carboxylate

tert-butyl 3-chloro-6-hydroxy-1H-indazole-1-carboxylate

Downstream raw materials:

(R)-tert-butyl 6-(2-((2-(3-amino-4-fluorophenyl)-2-(triethylsilyloxy)ethyl)(tert-butoxycarbonyl)amino)ethoxy)-3-chloroindazole-1-carboxylate