4-(4-acryloylamino-2-trifluoromethylbenzenesulfonyl)piperazine-1-carboxylic acid benzyl ester

Base Information

• Chemical Name: 4-(4-acryloylamino-2-trifluoromethylbenzenesulfonyl)piperazine-1-carboxylic acid benzyl ester
• CAS No.: 1306720-08-0
• Molecular Formula: C₂₂H₂₂F₃N₃O₅S
• Molecular Weight: 497.495
• Mol file: 1306720-08-0.mol

Synonyms:4-(4-acryloylamino-2-trifluoromethylbenzenesulfonyl)piperazine-1-carboxylic acid benzyl ester

Chemical Property of 4-(4-acryloylamino-2-trifluoromethylbenzenesulfonyl)piperazine-1-carboxylic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-acryloylamino-2-trifluoromethylbenzenesulfonyl)piperazine-1-carboxylic acid benzyl ester

There total 4 articles about 4-(4-acryloylamino-2-trifluoromethylbenzenesulfonyl)piperazine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

4-(4-amino-2-trifluoromethylbenzenesulfonyl)piperazine-1-carboxylic acid benzyl ester (1306723-08-9) + acryloyl chloride (814-68-6,25189-84-8) → 4-(4-acryloylamino-2-trifluoromethylbenzenesulfonyl)piperazine-1-carboxylic acid benzyl ester (1306720-08-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/jm201310y

Reference yield:

4-nitro-2-trifluoromethyl-aniline (121-01-7) → 4-(4-acryloylamino-2-trifluoromethylbenzenesulfonyl)piperazine-1-carboxylic acid benzyl ester (1306720-08-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogenchloride; acetic acid; sodium nitrite / water / 3 h / 15 °C / Inert atmosphere

1.2: 5 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

3.1: iron; ammonium chloride / ethanol; water / 3 h / 80 °C

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; iron; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; sodium nitrite; In tetrahydrofuran; ethanol; dichloromethane; water;

DOI:10.1021/jm201310y

Reference yield:

4-nitro-2-(trifluoromethyl)benzenesulfonyl chloride (444-46-2) → 4-(4-acryloylamino-2-trifluoromethylbenzenesulfonyl)piperazine-1-carboxylic acid benzyl ester (1306720-08-0)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

2: iron; ammonium chloride / ethanol; water / 3 h / 80 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

With iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; water;

DOI:10.1021/jm201310y

upstream raw materials:

4-(4-amino-2-trifluoromethylbenzenesulfonyl)piperazine-1-carboxylic acid benzyl ester

acryloyl chloride

4-(4-nitro-2-trifluoromethylbenzenesulfonyl)piperazine-1-carboxylic acid benzyl ester

4-nitro-2-trifluoromethyl-aniline