(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(7,8-dihydro-imidazo[2,1-i]purin-3-yl)-tetrahydro-furan-3-ol

Base Information

Chemical Name:(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(7,8-dihydro-imidazo[2,1-i]purin-3-yl)-tetrahydro-furan-3-ol
CAS No.:210689-70-6
Molecular Formula:C₃₃H₃₃N₅O₅
Molecular Weight:579.656
Hs Code.:

Synonyms:(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(7,8-dihydro-imidazo[2,1-i]purin-3-yl)-tetrahydro-furan-3-ol

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Chemical Property of (2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(7,8-dihydro-imidazo[2,1-i]purin-3-yl)-tetrahydro-furan-3-ol

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Technology Process of (2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(7,8-dihydro-imidazo[2,1-i]purin-3-yl)-tetrahydro-furan-3-ol

There total 6 articles about (2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(7,8-dihydro-imidazo[2,1-i]purin-3-yl)-tetrahydro-furan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: bis(4-methoxyphenyl)phenylmethylium tetrafluoroborate

: 210689-69-3
(2R,3S,5R)-5-(7,8-Dihydro-imidazo[2,1-i]purin-3-yl)-2-hydroxymethyl-tetrahydro-furan-3-ol

: 210689-70-6
(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(7,8-dihydro-imidazo[2,1-i]purin-3-yl)-tetrahydro-furan-3-ol

Guidance literature:: With 2,6-dimethylpyridine; lithium carbonate; for 6h; Ambient temperature;
DOI:10.1021/jo980170i

Reference yield:

: 890-38-0
2-deoxyinosine

: 210689-70-6
(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(7,8-dihydro-imidazo[2,1-i]purin-3-yl)-tetrahydro-furan-3-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) (CF₃CO)2O, 2.) SOCl₂, 3.) NaHCO₃ / 2.) DMF

2: 86 percent / imidazole / dimethylformamide / 3 h / Ambient temperature

3: 64 percent / methanol / 2 h / Heating

4: 67 percent / methyltriphenoxyphosphonium iodide, Et₃N / dimethylformamide / 0.75 h / Ambient temperature

5: 91 percent / triethylamine trihydrofluoride / tetrahydrofuran / 1 h / Ambient temperature

6: 62 percent / Li₂CO₃, 2,6-lutidine / 6 h / Ambient temperature

With 1H-imidazole; 2,6-dimethylpyridine; thionyl chloride; triethylamine trihydrofluoride; methyltriphenoxyphosphonium iodide; lithium carbonate; sodium hydrogencarbonate; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo980170i

Reference yield:

: 4594-45-0
6-chloropurine-2'-deoxyriboside

: 210689-70-6
(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(7,8-dihydro-imidazo[2,1-i]purin-3-yl)-tetrahydro-furan-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / imidazole / dimethylformamide / 3 h / Ambient temperature

2: 64 percent / methanol / 2 h / Heating

3: 67 percent / methyltriphenoxyphosphonium iodide, Et₃N / dimethylformamide / 0.75 h / Ambient temperature

4: 91 percent / triethylamine trihydrofluoride / tetrahydrofuran / 1 h / Ambient temperature

5: 62 percent / Li₂CO₃, 2,6-lutidine / 6 h / Ambient temperature

With 1H-imidazole; 2,6-dimethylpyridine; triethylamine trihydrofluoride; methyltriphenoxyphosphonium iodide; lithium carbonate; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo980170i