N-<1--L-leucyl>-L-prolyl>-3-(p-methoxyphenyl)-N-methyl-L-alanine, ester with (3S,4R,5S)-3-<(triisopropylsilyl)oxy>-4-<(2S,3R)-2-<(tert-butoxycarbonyl)amino>-3-hydroxybutyramido>-5-methylheptanoic acid, (1S,2S,3R)-4-hydroxy-1-isop

Base Information

Chemical Name:N-<1--L-leucyl>-L-prolyl>-3-(p-methoxyphenyl)-N-methyl-L-alanine, ester with (3S,4R,5S)-3-<(triisopropylsilyl)oxy>-4-<(2S,3R)-2-<(tert-butoxycarbonyl)amino>-3-hydroxybutyramido>-5-methylheptanoic acid, (1S,2S,3R)-4-hydroxy-1-isop
CAS No.:126587-63-1
Molecular Formula:C₆₆H₁₀₉N₅O₁₆Si
Molecular Weight:1256.7
Hs Code.:

N-<1-<N-<(benzyloxy)carbonyl>-L-leucyl>-L-prolyl>-3-(p-methoxyphenyl)-N-methyl-L-alanine, ester with (3S,4R,5S)-3-<(triisopropylsilyl)oxy>-4-<(2S,3R)-2-<(tert-butoxycarbonyl)amino>-3-hydroxybutyramido>-5-methylheptanoic acid, (1S,2S,3R)-4-hydroxy-1-isop

Synonyms:N-<1--L-leucyl>-L-prolyl>-3-(p-methoxyphenyl)-N-methyl-L-alanine, ester with (3S,4R,5S)-3-<(triisopropylsilyl)oxy>-4-<(2S,3R)-2-<(tert-butoxycarbonyl)amino>-3-hydroxybutyramido>-5-methylheptanoic acid, (1S,2S,3R)-4-hydroxy-1-isop

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Chemical Property of N-<1--L-leucyl>-L-prolyl>-3-(p-methoxyphenyl)-N-methyl-L-alanine, ester with (3S,4R,5S)-3-<(triisopropylsilyl)oxy>-4-<(2S,3R)-2-<(tert-butoxycarbonyl)amino>-3-hydroxybutyramido>-5-methylheptanoic acid, (1S,2S,3R)-4-hydroxy-1-isop

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Technology Process of N-<1--L-leucyl>-L-prolyl>-3-(p-methoxyphenyl)-N-methyl-L-alanine, ester with (3S,4R,5S)-3-<(triisopropylsilyl)oxy>-4-<(2S,3R)-2-<(tert-butoxycarbonyl)amino>-3-hydroxybutyramido>-5-methylheptanoic acid, (1S,2S,3R)-4-hydroxy-1-isop

There total 33 articles about N-<1--L-leucyl>-L-prolyl>-3-(p-methoxyphenyl)-N-methyl-L-alanine, ester with (3S,4R,5S)-3-<(triisopropylsilyl)oxy>-4-<(2S,3R)-2-<(tert-butoxycarbonyl)amino>-3-hydroxybutyramido>-5-methylheptanoic acid, (1S,2S,3R)-4-hydroxy-1-isop which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3160-59-6,4276-05-5,28862-89-7,55723-45-0,55723-48-3,127866-12-0
N-benzyloxycarbonylamino-D-alloisoleucine

: 126587-63-1
N-<1--L-leucyl>-L-prolyl>-3-(p-methoxyphenyl)-N-methyl-L-alanine, ester with (3S,4R,5S)-3-<(triisopropylsilyl)oxy>-4-<(2S,3R)-2-<(tert-butoxycarbonyl)amino>-3-hydroxybutyramido>-5-methylheptanoic acid, (1S,2S,3R)-4-hydroxy-1-isop

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) pentafluorophenyl trifluoroacetate, pyridine, 2.) LDA / 1.) CH₂Cl₂, 2.) THF

2: 83 percent / KBH₄ / ethanol

3: 2,6-lutidine

4: 98 percent / H₂ / 10percent Pd/C / ethyl acetate; methanol / 2068.6 Torr

5: 72 percent / BOP, DMAP / CH₂Cl₂ / Ambient temperature

6: 86 percent / aq. AcOH / tetrahydrofuran / 12 h

With pyridine; 2,6-dimethylpyridine; dmap; potassium borohydride; pentafluorophenyl trifloroacetate; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate;
DOI:10.1021/jo00097a022

Reference yield:

: 126587-70-0
(4R,5S)-4-<<(benzyloxy)carbonyl>amino>-3-hydroxy-5-methyl-heptanoic acid, (1S,2S,3R)-4-<(tert-butyldimethylsilyl)oxy>-1-isopropyl-2-(methoxymethoxy)-3-methylbutyl ester

: 126587-63-1
N-<1--L-leucyl>-L-prolyl>-3-(p-methoxyphenyl)-N-methyl-L-alanine, ester with (3S,4R,5S)-3-<(triisopropylsilyl)oxy>-4-<(2S,3R)-2-<(tert-butoxycarbonyl)amino>-3-hydroxybutyramido>-5-methylheptanoic acid, (1S,2S,3R)-4-hydroxy-1-isop

Guidance literature:: Multi-step reaction with 4 steps

1: 2,6-lutidine

2: 98 percent / H₂ / 10percent Pd/C / ethyl acetate; methanol / 2068.6 Torr

3: 72 percent / BOP, DMAP / CH₂Cl₂ / Ambient temperature

4: 86 percent / aq. AcOH / tetrahydrofuran / 12 h

With 2,6-dimethylpyridine; dmap; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jo00097a022

Reference yield:

: 126587-53-9
(3S,4S,5R)-6-[(tert-butyldimethylsilyl)oxy]-4-(methoxymethoxy)-2,5-dimethyl-3-hexanol acetate

: 126587-63-1
N-<1--L-leucyl>-L-prolyl>-3-(p-methoxyphenyl)-N-methyl-L-alanine, ester with (3S,4R,5S)-3-<(triisopropylsilyl)oxy>-4-<(2S,3R)-2-<(tert-butoxycarbonyl)amino>-3-hydroxybutyramido>-5-methylheptanoic acid, (1S,2S,3R)-4-hydroxy-1-isop

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) pentafluorophenyl trifluoroacetate, pyridine, 2.) LDA / 1.) CH₂Cl₂, 2.) THF

2: 83 percent / KBH₄ / ethanol

3: 2,6-lutidine

4: 98 percent / H₂ / 10percent Pd/C / ethyl acetate; methanol / 2068.6 Torr

5: 72 percent / BOP, DMAP / CH₂Cl₂ / Ambient temperature

6: 86 percent / aq. AcOH / tetrahydrofuran / 12 h

With pyridine; 2,6-dimethylpyridine; dmap; potassium borohydride; pentafluorophenyl trifloroacetate; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate;
DOI:10.1021/jo00097a022