C₁₈H₁₄N₄O

Base Information

• Chemical Name: C₁₈H₁₄N₄O
• CAS No.: 1547161-01-2
• Molecular Formula: C₁₈H₁₄N₄O
• Molecular Weight: 302.335
• Mol file: 1547161-01-2.mol

Synonyms:C₁₈H₁₄N₄O

Chemical Property of C₁₈H₁₄N₄O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₁₄N₄O

There total 5 articles about C₁₈H₁₄N₄O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

C18H15ClN4O (1547160-96-2) → C18H14N4O (1547161-01-2)

Guidance literature:

With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 110 ℃; for 24h;

DOI:10.1016/j.bmcl.2013.12.079

Reference yield:

7-fluoro-6-nitro-3H-quinazolin-4-one (162012-69-3) → C18H14N4O (1547161-01-2)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium hydride / tetrahydrofuran / 20 h / 75 °C

2: trichlorophosphate; thionyl chloride / 3 h / 90 °C

3: isopropyl alcohol / 2 h / 50 °C

4: ammonium chloride; iron / N,N-dimethyl-formamide; water / 1 h / 80 °C

5: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 24 h / 110 °C

With thionyl chloride; iron; sodium hydride; potassium carbonate; ammonium chloride; potassium iodide; trichlorophosphate; In tetrahydrofuran; water; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/j.bmcl.2013.12.079

Reference yield:

C18H13ClN4O3 (1547160-91-7) → C18H14N4O (1547161-01-2)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium chloride; iron / N,N-dimethyl-formamide; water / 1 h / 80 °C

2: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 24 h / 110 °C

With iron; potassium carbonate; ammonium chloride; potassium iodide; In water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2013.12.079

upstream raw materials:

7-fluoro-6-nitro-3H-quinazolin-4-one

C₁₀H₉N₃O₅

C₁₀H₇Cl₂N₃O₃

C₁₈H₁₃ClN₄O₃

Downstream raw materials:

C₂₆H₂₅N₅O₃

C₂₆H₂₅N₅O₂

C₂₈H₂₉N₅O₂

C₂₈H₂₉N₅O₂