(1s,4s)-4-(2-amino-5-(4-methoxybenzyloxy)phenylamino)-N-isopropylcyclohexanecarboxamide

Base Information

• Chemical Name: (1s,4s)-4-(2-amino-5-(4-methoxybenzyloxy)phenylamino)-N-isopropylcyclohexanecarboxamide
• CAS No.: 1357922-82-7
• Molecular Formula: C₂₄H₃₃N₃O₃
• Molecular Weight: 411.544

Synonyms:(1s,4s)-4-(2-amino-5-(4-methoxybenzyloxy)phenylamino)-N-isopropylcyclohexanecarboxamide

Chemical Property of (1s,4s)-4-(2-amino-5-(4-methoxybenzyloxy)phenylamino)-N-isopropylcyclohexanecarboxamide

Chemical Property:

Purity/Quality:

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Technology Process of (1s,4s)-4-(2-amino-5-(4-methoxybenzyloxy)phenylamino)-N-isopropylcyclohexanecarboxamide

There total 4 articles about (1s,4s)-4-(2-amino-5-(4-methoxybenzyloxy)phenylamino)-N-isopropylcyclohexanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(1s,4s)-N-isopropyl-4-((5-((4-methoxybenzyl)oxy)-2-nitrophenyl)amino)cyclohexanecarboxamide (1357922-80-5) → (1s,4s)-4-(2-amino-5-(4-methoxybenzyloxy)phenylamino)-N-isopropylcyclohexanecarboxamide (1357922-82-7)

Guidance literature:

With acetic acid; zinc; In methanol; at 20 ℃; for 3h;

DOI:10.1021/jm3005866

Reference yield:

2-fluoro-4-(4-methoxybenzyloxy)-1-nitrobenzene (1357922-78-1) → (1s,4s)-4-(2-amino-5-(4-methoxybenzyloxy)phenylamino)-N-isopropylcyclohexanecarboxamide (1357922-82-7)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetone / 80 °C

2: acetic acid; zinc / methanol / 3 h / 20 °C

With acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In methanol; acetone;

DOI:10.1021/jm3005866

Reference yield:

C10H20N2O*ClH (1357923-26-2) → (1s,4s)-4-(2-amino-5-(4-methoxybenzyloxy)phenylamino)-N-isopropylcyclohexanecarboxamide (1357922-82-7)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetone / 80 °C

2: acetic acid; zinc / methanol / 3 h / 20 °C

With acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In methanol; acetone;

DOI:10.1021/jm3005866

upstream raw materials:

C₁₀H₂₀N₂O*ClH

2-fluoro-4-(4-methoxybenzyloxy)-1-nitrobenzene

(1s,4s)-N-isopropyl-4-((5-((4-methoxybenzyl)oxy)-2-nitrophenyl)amino)cyclohexanecarboxamide

p-methoxybenzyl chloride

Downstream raw materials:

(E)-4-fluoro-N-(1-((1s,4s)-4-(isopropylcarbamoyl)cyclohexyl)-6-((4-methoxybenzyl)oxy)-1H-benzo[d]imidazol-2(3H)-ylidene)benzamide

(E)-4-fluoro-N-(6-hydroxy-1-((1s,4s)-4-(isopropylcarbamoyl)-cyclohexyl)-1H-benzo[d]imidazol-2(3H)-ylidene)benzamide

(E)-4-fluoro-N-(1-((1s,4s)-4-(isopropylcarbamoyl)-cyclohexyl)-6-(pyridin-2-yloxy)-1H-benzo[d]imidazol-2(3H)-ylidene)benzamide

(1s,4s)-4-(2-amino-6-(4-methoxybenzyloxy)-1H-benzo[d]imidazol-1-yl)-N-isopropylcyclohexanecarboxamide

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