4-[1-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-2-pyridin-4-yl-ethyl]-benzoic acid

Base Information

Chemical Name:4-[1-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-2-pyridin-4-yl-ethyl]-benzoic acid
CAS No.:1026535-58-9
Molecular Formula:C₂₅H₂₃F₂NO₄
Molecular Weight:439.459
Hs Code.:

Synonyms:4-[1-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-2-pyridin-4-yl-ethyl]-benzoic acid

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Chemical Property of 4-[1-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-2-pyridin-4-yl-ethyl]-benzoic acid

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Technology Process of 4-[1-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-2-pyridin-4-yl-ethyl]-benzoic acid

There total 7 articles about 4-[1-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-2-pyridin-4-yl-ethyl]-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 552287-71-5
(+/-)-4-{2-[(3-cyclobutyloxy-4-difluoromethoxy)phenyl]-2-[4-(1-hydroxymethyl)phenyl]ethyl}pyridine

: 1026535-58-9
4-[1-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-2-pyridin-4-yl-ethyl]-benzoic acid

Guidance literature:: With potassium permanganate; In acetone; at 20 ℃; for 2h;
DOI:10.1021/jm0204542

Reference yield:

: 54401-85-3
pyridin-4-yl-acetic acid ethyl ester

: 1026535-58-9
4-[1-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-2-pyridin-4-yl-ethyl]-benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: KHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide; toluene / 0.33 h / 20 °C

1.2: tetrahydrofuran; hexamethylphosphoric acid triamide; toluene / 15 h / 20 °C

2.1: 1.80 g / aq. LiOH / tetrahydrofuran; methanol / 4 h / 70 °C

3.1: KMnO₄ / acetone / 2 h / 20 °C

With lithium hydroxide; potassium permanganate; potassium hexamethylsilazane; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; acetone; toluene;
DOI:10.1021/jm0204542

Reference yield:

: 133776-42-8
4-bromo-2-(tert-butyldiphenylsilyloxymethyl)benzene

: 1026535-58-9
4-[1-(3-cyclobutoxy-4-difluoromethoxy-phenyl)-2-pyridin-4-yl-ethyl]-benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 62 percent / tetrahydrofuran; hexane / 2.5 h

2.1: SOCl₂; pyridine / toluene / 0.42 h / 20 °C

3.1: KHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide; toluene / 0.33 h / 20 °C

3.2: tetrahydrofuran; hexamethylphosphoric acid triamide; toluene / 15 h / 20 °C

4.1: 1.80 g / aq. LiOH / tetrahydrofuran; methanol / 4 h / 70 °C

5.1: KMnO₄ / acetone / 2 h / 20 °C

With pyridine; lithium hydroxide; potassium permanganate; n-butyllithium; thionyl chloride; potassium hexamethylsilazane; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; acetone; toluene;
DOI:10.1021/jm0204542