tert-butyl cyclopropyl(2-oxo-2-((4'-(trifluoromethyl)biphenyl-3-yl)methylamino)ethyl)carbamate

Base Information

Chemical Name:tert-butyl cyclopropyl(2-oxo-2-((4'-(trifluoromethyl)biphenyl-3-yl)methylamino)ethyl)carbamate
CAS No.:1590397-80-0
Molecular Formula:C₂₄H₂₇F₃N₂O₃
Molecular Weight:448.485
Hs Code.:

Synonyms:tert-butyl cyclopropyl(2-oxo-2-((4'-(trifluoromethyl)biphenyl-3-yl)methylamino)ethyl)carbamate

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Chemical Property of tert-butyl cyclopropyl(2-oxo-2-((4'-(trifluoromethyl)biphenyl-3-yl)methylamino)ethyl)carbamate

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Technology Process of tert-butyl cyclopropyl(2-oxo-2-((4'-(trifluoromethyl)biphenyl-3-yl)methylamino)ethyl)carbamate

There total 4 articles about tert-butyl cyclopropyl(2-oxo-2-((4'-(trifluoromethyl)biphenyl-3-yl)methylamino)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-((tert-butoxycarbonyl)(cyclopropyl)amino)acetic acid

: 472964-40-2
[3-[4-(trifluoromethyl)phenyl] phenyl]methanamine

: 1590397-80-0
tert-butyl cyclopropyl(2-oxo-2-((4'-(trifluoromethyl)biphenyl-3-yl)methylamino)ethyl)carbamate

Guidance literature:: With O-Benzotriazol-1-yl-N,N,N',N'-bis(tetramethylene)uronium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 2h;

Reference yield:

: 10269-01-9
3-bromobenzylamine

: 1590397-80-0
tert-butyl cyclopropyl(2-oxo-2-((4'-(trifluoromethyl)biphenyl-3-yl)methylamino)ethyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / Inert atmosphere; Reflux

2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; O-Benzotriazol-1-yl-N,N,N',N'-bis(tetramethylene)uronium hexafluorophosphate / N,N-dimethyl-formamide / 2 h

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; O-Benzotriazol-1-yl-N,N,N',N'-bis(tetramethylene)uronium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

Reference yield:

: 402-43-7
p-trifluoromethylphenyl bromide

: 1590397-80-0
tert-butyl cyclopropyl(2-oxo-2-((4'-(trifluoromethyl)biphenyl-3-yl)methylamino)ethyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 16 h / 120 °C / Inert atmosphere; Sealed tube

2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; O-Benzotriazol-1-yl-N,N,N',N'-bis(tetramethylene)uronium hexafluorophosphate / N,N-dimethyl-formamide / 2 h

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; O-Benzotriazol-1-yl-N,N,N',N'-bis(tetramethylene)uronium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; 1: |Suzuki Coupling;