Technology Process of diethyl 3,4,5-trimethoxybenzyl phosphate
There total 1 articles about diethyl 3,4,5-trimethoxybenzyl phosphate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap; triethylamine;
In
tetrahydrofuran;
at 20 ℃;
for 4h;
DOI:10.1021/ol0616790
- Guidance literature:
-
5-bromo-2,4-di(tert-butoxy)pyrimidine;
With
TurboGrignard;
In
tetrahydrofuran; 1,2-dimethoxyethane;
at 0 ℃;
for 4h;
With
copper(I) bromide; triethyl phosphite;
In
tetrahydrofuran; 1,2-dimethoxyethane;
at -15 ℃;
for 0.166667h;
diethyl 3,4,5-trimethoxybenzyl phosphate;
With
tetra-(n-butyl)ammonium iodide;
In
tetrahydrofuran; 1,2-dimethoxyethane;
at 60 ℃;
for 1.5h;
DOI:10.1021/ol0616790
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: i-PrMgCl*LiCl / tetrahydrofuran; 1,2-dimethoxy-ethane / 4 h / 0 °C
1.2: CuBr; P(OEt)3 / 1,2-dimethoxy-ethane; tetrahydrofuran / 0.17 h / -15 °C
1.3: 81 percent / tetrabutylammonium iodide / tetrahydrofuran; 1,2-dimethoxy-ethane / 1.5 h / 60 °C
2.1: 87 percent / aq. HCl / methanol / 0.25 h / 20 °C
3.1: 86 percent / N,N-dimethylbenzenamine; POCl3 / 1 h / 110 °C
4.1: 85 percent / NH3 / methanol / 6 h / 175 °C
With
hydrogenchloride; TurboGrignard; ammonia; N,N-dimethyl-aniline; trichlorophosphate;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane;
DOI:10.1021/ol0616790
