(3R)-1-(2-fluoro-5-methoxyphenyl)-3,7-dimethyl-1-(phenylsulfanyl)oct-6-en-3-ol

Base Information

Chemical Name:(3R)-1-(2-fluoro-5-methoxyphenyl)-3,7-dimethyl-1-(phenylsulfanyl)oct-6-en-3-ol
CAS No.:1412393-14-6
Molecular Formula:C₂₃H₂₉FO₂S
Molecular Weight:388.546
Hs Code.:

Synonyms:(3R)-1-(2-fluoro-5-methoxyphenyl)-3,7-dimethyl-1-(phenylsulfanyl)oct-6-en-3-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R)-1-(2-fluoro-5-methoxyphenyl)-3,7-dimethyl-1-(phenylsulfanyl)oct-6-en-3-ol

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Technology Process of (3R)-1-(2-fluoro-5-methoxyphenyl)-3,7-dimethyl-1-(phenylsulfanyl)oct-6-en-3-ol

There total 5 articles about (3R)-1-(2-fluoro-5-methoxyphenyl)-3,7-dimethyl-1-(phenylsulfanyl)oct-6-en-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1412393-12-4
1-fluoro-4-methoxy-2-[ (phenylsulfanyl)methyl]benzene

: 138944-69-1
(2R)-2-methyl-2-(4-methylpent-3-en-1-yl)oxirane

: 1412393-14-6
(3R)-1-(2-fluoro-5-methoxyphenyl)-3,7-dimethyl-1-(phenylsulfanyl)oct-6-en-3-ol

Guidance literature:: 1-fluoro-4-methoxy-2-[ (phenylsulfanyl)methyl]benzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Inert atmosphere;

(2R)-2-methyl-2-(4-methylpent-3-en-1-yl)oxirane; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 20h; Inert atmosphere;
DOI:10.1002/hlca.201200312

Reference yield:

: 43161-11-1
5-iodo-2-methylpent-2-ene

: 1412393-14-6
(3R)-1-(2-fluoro-5-methoxyphenyl)-3,7-dimethyl-1-(phenylsulfanyl)oct-6-en-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium; diisopropylamine / hexane; tetrahydrofuran / 0.5 h / -78 °C

1.2: 20 h / -78 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 20 h / -78 - 20 °C / Inert atmosphere

3.1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / dichloromethane; water / 0.25 h / 20 °C

3.2: 2 h / 0 - 20 °C

4.1: n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

4.2: 20 h / -78 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; n-butyllithium; N-benzyl-N,N,N-triethylammonium chloride; diisopropylamine; sodium hydroxide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; 1.1: |Seebach Umpolung;
DOI:10.1002/hlca.201200312

Reference yield:

: 161643-29-4
(2-fluoro-5-methoxyphenyl)methanol

: 1412393-14-6
(3R)-1-(2-fluoro-5-methoxyphenyl)-3,7-dimethyl-1-(phenylsulfanyl)oct-6-en-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine; tributylphosphine / 0.33 h / 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

2.2: 20 h / -78 - 20 °C / Inert atmosphere

With pyridine; n-butyllithium; tributylphosphine; In tetrahydrofuran; hexane;
DOI:10.1002/hlca.201200312