C₂₀H₁₃FN₂O

Base Information

• Chemical Name: C₂₀H₁₃FN₂O
• CAS No.: 1367127-56-7
• Molecular Formula: C₂₀H₁₃FN₂O
• Molecular Weight: 316.334
• Mol file: 1367127-56-7.mol

Synonyms:C₂₀H₁₃FN₂O

Chemical Property of C₂₀H₁₃FN₂O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₁₃FN₂O

There total 6 articles about C₂₀H₁₃FN₂O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Bromo-4-fluorobenzene (460-00-4) → C20H13FN2O (1367127-56-7)

Guidance literature:

Multi-step reaction with 4 steps

1: caesium carbonate; dimethylaminoacetic acid / copper(l) iodide / 1,4-dioxane / 20 h / 90 °C

2: potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate / palladium diacetate / toluene / 20 h / 110 °C

3: trichlorophosphate / N,N-dimethyl-formamide; toluene / Reflux

4: tetrabutyl ammonium fluoride / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / tetrahydrofuran / 3 h / Inert atmosphere; Heating

With dimethylaminoacetic acid; tetrabutyl ammonium fluoride; potassium carbonate; caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate; trichlorophosphate; copper(l) iodide; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; toluene;

Reference yield:

2-Cyanopyridine (100-70-9,1232006-36-8) → C20H13FN2O (1367127-56-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: dihydrogen peroxide / methyltrioxorhenium(VII) / dichloromethane; water / 6 h / 20 °C

1.2: 1 h / 20 °C

2.1: potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate / palladium diacetate / toluene / 20 h / 110 °C

3.1: trichlorophosphate / N,N-dimethyl-formamide; toluene / Reflux

4.1: tetrabutyl ammonium fluoride / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / tetrahydrofuran / 3 h / Inert atmosphere; Heating

With tetrabutyl ammonium fluoride; dihydrogen peroxide; potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate; trichlorophosphate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; palladium diacetate; methyltrioxorhenium(VII); In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

4-Fluorophenol (371-41-5) → C20H13FN2O (1367127-56-7)

Guidance literature:

Multi-step reaction with 4 steps

1: caesium carbonate; dimethylaminoacetic acid / copper(l) iodide / 1,4-dioxane / 20 h / 90 °C

2: potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate / palladium diacetate / toluene / 20 h / 110 °C

3: trichlorophosphate / N,N-dimethyl-formamide; toluene / Reflux

4: tetrabutyl ammonium fluoride / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / tetrahydrofuran / 3 h / Inert atmosphere; Heating

With dimethylaminoacetic acid; tetrabutyl ammonium fluoride; potassium carbonate; caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate; trichlorophosphate; copper(l) iodide; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; toluene;

upstream raw materials:

2-Cyanopyridine

1-Bromo-4-fluorobenzene

4-Fluorophenol

1-bromo-4-(4-fluorophenoxy) benzene

Downstream raw materials:

C₂₀H₁₅FN₂O₃

C₂₀H₁₇FN₂O₄