N-cyclopropylmethyl-14β-[4-(4-chlorophenyl)-butanamino]-7,8-dihydronormorphinone ethylene ketal

Base Information

Chemical Name:N-cyclopropylmethyl-14β-[4-(4-chlorophenyl)-butanamino]-7,8-dihydronormorphinone ethylene ketal
CAS No.:913837-47-5
Molecular Formula:C₃₂H₃₉ClN₂O₄
Molecular Weight:551.126
Hs Code.:

Synonyms:N-cyclopropylmethyl-14β-[4-(4-chlorophenyl)-butanamino]-7,8-dihydronormorphinone ethylene ketal

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-cyclopropylmethyl-14β-[4-(4-chlorophenyl)-butanamino]-7,8-dihydronormorphinone ethylene ketal

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Technology Process of N-cyclopropylmethyl-14β-[4-(4-chlorophenyl)-butanamino]-7,8-dihydronormorphinone ethylene ketal

There total 2 articles about N-cyclopropylmethyl-14β-[4-(4-chlorophenyl)-butanamino]-7,8-dihydronormorphinone ethylene ketal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 913837-48-6
C₂₂H₂₈N₂O₄

: 1-bromo-4-(4-chlorophenyl)butane

: 913837-47-5
N-cyclopropylmethyl-14β-[4-(4-chlorophenyl)-butanamino]-7,8-dihydronormorphinone ethylene ketal

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃;
DOI:10.1021/jm060595u

Reference yield:

: C₂₃H₃₀N₂O₄

: 913837-47-5
N-cyclopropylmethyl-14β-[4-(4-chlorophenyl)-butanamino]-7,8-dihydronormorphinone ethylene ketal

Guidance literature:: Multi-step reaction with 2 steps

1: 40 percent / BBr₃ / CH₂Cl₂ / 0.5 h / -30 - 20 °C

2: 49 percent / potassium carbonate / dimethylformamide / 90 °C

With boron tribromide; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm060595u