N-<2-<2-(1-Cyanoethenyl)-1H-indol-3-yl>ethyl>-3-(carbomethoxy)pyridinium p-toluenesulfonate monohydrate

Base Information

Chemical Name:N-<2-<2-(1-Cyanoethenyl)-1H-indol-3-yl>ethyl>-3-(carbomethoxy)pyridinium p-toluenesulfonate monohydrate
CAS No.:77903-92-5
Molecular Formula:C₇H₇O₃S*C₂₀H₁₈N₃O₂
Molecular Weight:503.579
Hs Code.:

Synonyms:N-<2-<2-(1-Cyanoethenyl)-1H-indol-3-yl>ethyl>-3-(carbomethoxy)pyridinium p-toluenesulfonate monohydrate

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Chemical Property of N-<2-<2-(1-Cyanoethenyl)-1H-indol-3-yl>ethyl>-3-(carbomethoxy)pyridinium p-toluenesulfonate monohydrate

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Technology Process of N-<2-<2-(1-Cyanoethenyl)-1H-indol-3-yl>ethyl>-3-(carbomethoxy)pyridinium p-toluenesulfonate monohydrate

There total 16 articles about N-<2-<2-(1-Cyanoethenyl)-1H-indol-3-yl>ethyl>-3-(carbomethoxy)pyridinium p-toluenesulfonate monohydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 77903-79-8
N-<2-<2-(1-Cyanoethyl)-1H-indol-3-yl>ethyl>-3-(carbomethoxy)pyridinium p-toluenesulfonate hemihydrate

: 77903-92-5
N-<2-<2-(1-Cyanoethenyl)-1H-indol-3-yl>ethyl>-3-(carbomethoxy)pyridinium p-toluenesulfonate monohydrate

Guidance literature:: With tert-butylhypochlorite; In acetonitrile; for 0.5h;
DOI:10.1021/jo00329a029

Reference yield:

: 6250-88-0
4,9-Dihydropyrano<3,4-b>indol-1(3H)-on

: 77903-92-5
N-<2-<2-(1-Cyanoethenyl)-1H-indol-3-yl>ethyl>-3-(carbomethoxy)pyridinium p-toluenesulfonate monohydrate

Guidance literature:: Multi-step reaction with 11 steps

1: 90 percent / LiOH / methanol / 2 h

2: 89 percent / diethyl ether; tetrahydrofuran / 3 h

3: 95 percent / Hydrazine Hydrate, KOH / bis-(2-hydroxy-ethyl) ether / 7 h / 100 - 200 °C

4: 98.5 percent / Imidazole / dimethylformamide / 168 h

5: tert-Butylhypochlorite, Triethylamine / CH₂Cl₂ / 1 h / -78 °C

6: 74 percent / methanol / 120 h

7: 90 percent / ethyl acetate / 4 h / Ambient temperature

8: 91 percent / 18-crown-6 / acetonitrile / 48 h / 60 °C

9: γ-Collidine / benzene / 1 h / 25 °C

10: benzene

11: 40 percent / tert-Butyl hypochlorite / acetonitrile / 0.5 h

With 1H-imidazole; 2,4,6-trimethyl-pyridine; potassium hydroxide; lithium hydroxide; 18-crown-6 ether; tert-butylhypochlorite; hydrazine hydrate; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; diethylene glycol; benzene;
DOI:10.1021/jo00329a029

Reference yield:

: 526-55-6,930395-07-6
2-(3-indole)-ethanol

: 77903-92-5
N-<2-<2-(1-Cyanoethenyl)-1H-indol-3-yl>ethyl>-3-(carbomethoxy)pyridinium p-toluenesulfonate monohydrate

Guidance literature:: Multi-step reaction with 6 steps

1: 78 percent / Mercuric acetate / 69 h / 25 °C

2: 70 percent / Trifluoroacetic acid / CH₂Cl₂ / 2.25 h / 15 - 18 °C

3: 67 percent / ZnCl₂ / 72 h / 105 °C

4: γ-Collidine / benzene / 1 h / 25 °C

5: benzene

6: 40 percent / tert-Butyl hypochlorite / acetonitrile / 0.5 h

With 2,4,6-trimethyl-pyridine; tert-butylhypochlorite; mercury(II) diacetate; trifluoroacetic acid; zinc(II) chloride; In dichloromethane; acetonitrile; benzene;
DOI:10.1021/jo00329a029