7-(2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl)-2-(isobutyrylamino)-5-{3-[di(prop-2-ynyl)amino]prop-1-ynyl}-3,7-dihydro-4H-pyrrolo-[2,3-d]pyrimidin-4-one

Base Information

• Chemical Name: 7-(2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl)-2-(isobutyrylamino)-5-{3-[di(prop-2-ynyl)amino]prop-1-ynyl}-3,7-dihydro-4H-pyrrolo-[2,3-d]pyrimidin-4-one
• CAS No.: 1203676-64-5
• Molecular Formula: C₄₅H₄₅N₅O₇
• Molecular Weight: 767.882

Synonyms:7-(2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl)-2-(isobutyrylamino)-5-{3-[di(prop-2-ynyl)amino]prop-1-ynyl}-3,7-dihydro-4H-pyrrolo-[2,3-d]pyrimidin-4-one

Chemical Property of 7-(2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl)-2-(isobutyrylamino)-5-{3-[di(prop-2-ynyl)amino]prop-1-ynyl}-3,7-dihydro-4H-pyrrolo-[2,3-d]pyrimidin-4-one

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Technology Process of 7-(2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl)-2-(isobutyrylamino)-5-{3-[di(prop-2-ynyl)amino]prop-1-ynyl}-3,7-dihydro-4H-pyrrolo-[2,3-d]pyrimidin-4-one

There total 1 articles about 7-(2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl)-2-(isobutyrylamino)-5-{3-[di(prop-2-ynyl)amino]prop-1-ynyl}-3,7-dihydro-4H-pyrrolo-[2,3-d]pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

7-(2-deoxy-β-D-erythro-pentofuranosyl)-2-(isobutyrylamino)-5-{3-[di(prop-2-ynyl)amino]prop-1-ynyl}-3,7-dihydro-4H-pyrrolo-[2,3-d]pyrimidin-4-one (1203676-63-4) + 4,4'-dimethoxytrityl chloride (40615-36-9) → 7-(2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl)-2-(isobutyrylamino)-5-{3-[di(prop-2-ynyl)amino]prop-1-ynyl}-3,7-dihydro-4H-pyrrolo-[2,3-d]pyrimidin-4-one (1203676-64-5)

Guidance literature:

With pyridine; at 20 ℃; for 8h;

DOI:10.1021/jo902300e

Reference yield: 82.0%

7-(2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl)-2-(isobutyrylamino)-5-{3-[di(prop-2-ynyl)amino]prop-1-ynyl}-3,7-dihydro-4H-pyrrolo-[2,3-d]pyrimidin-4-one (1203676-64-5) + 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) → C54H62N7O8P (1203676-65-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/jo902300e

upstream raw materials:

7-(2-deoxy-β-D-erythro-pentofuranosyl)-2-(isobutyrylamino)-5-{3-[di(prop-2-ynyl)amino]prop-1-ynyl}-3,7-dihydro-4H-pyrrolo-[2,3-d]pyrimidin-4-one

4,4'-dimethoxytrityl chloride

Downstream raw materials:

C₅₄H₆₂N₇O₈P

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