O-(paclitaxel-2'-yl) 3-maleimidopropionate

Base Information

• Chemical Name: O-(paclitaxel-2'-yl) 3-maleimidopropionate
• CAS No.: 254893-84-0
• Molecular Formula: C₅₄H₅₆N₂O₁₇
• Molecular Weight: 1005.04
• Mol file: 254893-84-0.mol

Synonyms:O-(paclitaxel-2'-yl) 3-maleimidopropionate

Chemical Property of O-(paclitaxel-2'-yl) 3-maleimidopropionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O-(paclitaxel-2'-yl) 3-maleimidopropionate

There total 2 articles about O-(paclitaxel-2'-yl) 3-maleimidopropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

3-maleimidopropionic anhydride + taxol (33069-62-4) → O-(paclitaxel-2'-yl) 3-maleimidopropionate (254893-84-0)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmcl.2006.02.035

Reference yield: 63.0%

3-maleimidepropionic acid (7423-55-4) + taxol (33069-62-4) → O-(paclitaxel-2'-yl) 3-maleimidopropionate (254893-84-0)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃;

Reference yield: 53.0%

O-(paclitaxel-2'-yl) 3-maleimidopropionate (254893-84-0) + CRRMKWKK-NH2 → C103H143N21O25S2

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2006.02.035

upstream raw materials:

taxol

3-maleimidepropionic acid