1H-Pyrrolizine-3-carboxylicacid,hexahydro-5-oxo-,cis-(9CI)

Base Information

Chemical Name:1H-Pyrrolizine-3-carboxylicacid,hexahydro-5-oxo-,cis-(9CI)
CAS No.:106281-22-5
Molecular Formula:C₈H₁₁NO₃
Molecular Weight:169.18
Hs Code.:
Mol file:106281-22-5.mol

Synonyms:1H-Pyrrolizine-3-carboxylicacid, hexahydro-5-oxo-, cis- (9CI); 1H-Pyrrolizine-3-carboxylic acid,hexahydro-5-oxo-, cis-(?à)-

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Pyrrolizine-3-carboxylicacid,hexahydro-5-oxo-,cis-(9CI)

Chemical Property:

PSA：57.61000
LogP:0.16230

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrolizine-3-carboxylicacid,hexahydro-5-oxo-,cis-(9CI)

There total 12 articles about 1H-Pyrrolizine-3-carboxylicacid,hexahydro-5-oxo-,cis-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 106281-20-3
methyl 5-(β-methoxycarbonylethyl)-1H-pyrrole-2-carboxylate

: 106281-22-5,106281-23-6,107294-50-8,586409-94-1
(3α,7aα)-(+/-)-hexahydro-5-oxo-1H-pyrrolizine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / H₂ / 5percent Rh/Al₂O₃ / acetic acid / 4 h / 3102.9 Torr / Ambient temperature

2: toluene / 24 h / Heating

3: 1N aq. NaOH / tetrahydrofuran / 1 h

With sodium hydroxide; hydrogen; Rh/Al₂O₃; In tetrahydrofuran; acetic acid; toluene;

Reference yield:

: 106281-20-3
methyl 5-(β-methoxycarbonylethyl)-1H-pyrrole-2-carboxylate

: 106281-22-5,106281-23-6,107294-50-8,586409-94-1
(3β,7aα)-(+/-)-hexahydro-5-oxo-1H-pyrrolizine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / H₂ / 5percent Rh/Al₂O₃ / acetic acid / 4 h / 3102.9 Torr / Ambient temperature

2: acetic acid / 24 h / Heating

3: 1N aq. NaOH / tetrahydrofuran / 1 h

With sodium hydroxide; hydrogen; Rh/Al₂O₃; In tetrahydrofuran; acetic acid;

Reference yield:

: 106281-18-9
methyl 5-<(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl>-1H-pyrrole-2-carboxylate

: 106281-22-5,106281-23-6,107294-50-8,586409-94-1
(3α,7aα)-(+/-)-hexahydro-5-oxo-1H-pyrrolizine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 68 percent / H₂ / W-4 Raney nickel / ethanol / 2 h / 3102.9 Torr / Ambient temperature

2: 1) glacial acetic acid, 2) p-toluenesulfonic acid / 1) reflux, 17 h, 2) reflux, 2h

3: 79 percent / H₂ / 5percent Rh/Al₂O₃ / acetic acid / 4 h / 3102.9 Torr / Ambient temperature

4: toluene / 24 h / Heating

5: 1N aq. NaOH / tetrahydrofuran / 1 h

With sodium hydroxide; hydrogen; toluene-4-sulfonic acid; acetic acid; Rh/Al₂O₃; W-4 Raney nickel; In tetrahydrofuran; ethanol; acetic acid; toluene;