N'-benzyl-2'-O,3'-N-(carbonimidoyl)-3'-N-demethyl-6-O-methyl-9a-aza-9a-homoerythromycin A

Base Information

Chemical Name:N'-benzyl-2'-O,3'-N-(carbonimidoyl)-3'-N-demethyl-6-O-methyl-9a-aza-9a-homoerythromycin A
CAS No.:1192304-15-6
Molecular Formula:C₄₅H₇₃N₃O₁₃
Molecular Weight:864.087
Hs Code.:

Synonyms:N'-benzyl-2'-O,3'-N-(carbonimidoyl)-3'-N-demethyl-6-O-methyl-9a-aza-9a-homoerythromycin A

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Chemical Property of N'-benzyl-2'-O,3'-N-(carbonimidoyl)-3'-N-demethyl-6-O-methyl-9a-aza-9a-homoerythromycin A

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Technology Process of N'-benzyl-2'-O,3'-N-(carbonimidoyl)-3'-N-demethyl-6-O-methyl-9a-aza-9a-homoerythromycin A

There total 4 articles about N'-benzyl-2'-O,3'-N-(carbonimidoyl)-3'-N-demethyl-6-O-methyl-9a-aza-9a-homoerythromycin A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1192304-57-6
3'-N-(benzylthiocarbamoyl)-3'-N-demethyl-6-O-methyl-9a-aza-9a-homoerythromycin A

: 1192304-15-6
N'-benzyl-2'-O,3'-N-(carbonimidoyl)-3'-N-demethyl-6-O-methyl-9a-aza-9a-homoerythromycin A

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In chloroform; at 20 ℃; for 24h;

Reference yield:

: 906452-70-8
3'-N-demethyl-6-O-methyl-9a-aza-9a-homoerythromycin A

: 622-78-6
Benzyl isothiocyanate

: 1192304-15-6
N'-benzyl-2'-O,3'-N-(carbonimidoyl)-3'-N-demethyl-6-O-methyl-9a-aza-9a-homoerythromycin A

Guidance literature:: 3'-N-demethyl-6-O-methyl-9a-aza-9a-homoerythromycin A; Benzyl isothiocyanate; With triethylamine; In acetonitrile; at 60 ℃; for 2h;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 60 ℃;
DOI:10.1021/jm300356u

Reference yield:

: 210912-02-0
6-O-methyl-9a-aza-9a-homoerythromycin A

: 1192304-15-6
N'-benzyl-2'-O,3'-N-(carbonimidoyl)-3'-N-demethyl-6-O-methyl-9a-aza-9a-homoerythromycin A

Guidance literature:: Multi-step reaction with 3 steps

1: water; iodine; sodium acetate / methanol / 20 °C / irradiated with 500 W halogen lamp

2: triethylamine / acetonitrile / 24 h / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / chloroform / 24 h / 20 °C

With water; iodine; sodium acetate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; chloroform; acetonitrile;