1-(3-(6-oxo-7,8-diphenyl-3,4,6,8a-tetrahydro-2H-pyrrolo[2,1-b]-1,3-thiazin-8a-ylthio)propyl)-3,4-diphenyl-1H-pyrrole-2,5-dione

Base Information

• Chemical Name: 1-(3-(6-oxo-7,8-diphenyl-3,4,6,8a-tetrahydro-2H-pyrrolo[2,1-b]-1,3-thiazin-8a-ylthio)propyl)-3,4-diphenyl-1H-pyrrole-2,5-dione
• CAS No.: 1384256-66-9
• Molecular Formula: C₃₈H₃₂N₂O₃S₂
• Molecular Weight: 628.816
• Mol file: 1384256-66-9.mol

Synonyms:1-(3-(6-oxo-7,8-diphenyl-3,4,6,8a-tetrahydro-2H-pyrrolo[2,1-b]-1,3-thiazin-8a-ylthio)propyl)-3,4-diphenyl-1H-pyrrole-2,5-dione

Chemical Property of 1-(3-(6-oxo-7,8-diphenyl-3,4,6,8a-tetrahydro-2H-pyrrolo[2,1-b]-1,3-thiazin-8a-ylthio)propyl)-3,4-diphenyl-1H-pyrrole-2,5-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3-(6-oxo-7,8-diphenyl-3,4,6,8a-tetrahydro-2H-pyrrolo[2,1-b]-1,3-thiazin-8a-ylthio)propyl)-3,4-diphenyl-1H-pyrrole-2,5-dione

There total 4 articles about 1-(3-(6-oxo-7,8-diphenyl-3,4,6,8a-tetrahydro-2H-pyrrolo[2,1-b]-1,3-thiazin-8a-ylthio)propyl)-3,4-diphenyl-1H-pyrrole-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

(Z)-3-(dichlorophenylacetyl)-2-(Z)-benzylidene-1,3-thiazinane (1384256-41-0) → 1-(3-(6-oxo-7,8-diphenyl-3,4,6,8a-tetrahydro-2H-pyrrolo[2,1-b]-1,3-thiazin-8a-ylthio)propyl)-3,4-diphenyl-1H-pyrrole-2,5-dione (1384256-66-9) + 1,1'-[3,3'-disulfanediylbis(propane-3,1-diyl)]bis(3,4-diphenyl-1H-pyrrole-2,5-dione) (1384256-65-8)

Guidance literature:

(Z)-3-(dichlorophenylacetyl)-2-(Z)-benzylidene-1,3-thiazinane; With N,N,N,N,-tetramethylethylenediamine; sodium carbonate; copper(l) chloride; In acetonitrile; at 30 ℃; Inert atmosphere;

With water; In acetonitrile; Inert atmosphere;

DOI:10.1016/j.tet.2012.04.117

Reference yield:

N-(3-hydroxypropyl)-2-phenylacetamide (124932-16-7) → 1-(3-(6-oxo-7,8-diphenyl-3,4,6,8a-tetrahydro-2H-pyrrolo[2,1-b]-1,3-thiazin-8a-ylthio)propyl)-3,4-diphenyl-1H-pyrrole-2,5-dione (1384256-66-9) + 1,1'-[3,3'-disulfanediylbis(propane-3,1-diyl)]bis(3,4-diphenyl-1H-pyrrole-2,5-dione) (1384256-65-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: Lawessons reagent / toluene / 1.5 h / 120 °C / Inert atmosphere

2.1: pyridine / dichloromethane / 24.5 h / 0 - 25 °C

3.1: N,N,N,N,-tetramethylethylenediamine; sodium carbonate; copper(l) chloride / acetonitrile / 30 °C / Inert atmosphere

3.2: Inert atmosphere

With Lawessons reagent; pyridine; N,N,N,N,-tetramethylethylenediamine; sodium carbonate; copper(l) chloride; In dichloromethane; toluene; acetonitrile;

DOI:10.1016/j.tet.2012.04.117

Reference yield:

5,6-dihydro-2-benzyl-4H-1,3-thiazine (25478-53-9) → 1-(3-(6-oxo-7,8-diphenyl-3,4,6,8a-tetrahydro-2H-pyrrolo[2,1-b]-1,3-thiazin-8a-ylthio)propyl)-3,4-diphenyl-1H-pyrrole-2,5-dione (1384256-66-9) + 1,1'-[3,3'-disulfanediylbis(propane-3,1-diyl)]bis(3,4-diphenyl-1H-pyrrole-2,5-dione) (1384256-65-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine / dichloromethane / 24.5 h / 0 - 25 °C

2.1: N,N,N,N,-tetramethylethylenediamine; sodium carbonate; copper(l) chloride / acetonitrile / 30 °C / Inert atmosphere

2.2: Inert atmosphere

With pyridine; N,N,N,N,-tetramethylethylenediamine; sodium carbonate; copper(l) chloride; In dichloromethane; acetonitrile;

DOI:10.1016/j.tet.2012.04.117

upstream raw materials:

(Z)-3-(dichlorophenylacetyl)-2-(Z)-benzylidene-1,3-thiazinane

N-(3-hydroxypropyl)-2-phenylacetamide

5,6-dihydro-2-benzyl-4H-1,3-thiazine

benzeneacetic acid methyl ester