2-acetamido-4-methylphenyl acetate

Base Information

• Chemical Name: 2-acetamido-4-methylphenyl acetate
• CAS No.: 75813-74-0
• Molecular Formula: C₁₁H₁₃NO₃
• Molecular Weight: 207.229
• Mol file: 75813-74-0.mol

Synonyms:2-acetamido-4-methylphenyl acetate

Chemical Property of 2-acetamido-4-methylphenyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-acetamido-4-methylphenyl acetate

There total 4 articles about 2-acetamido-4-methylphenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

acetic anhydride (108-24-7) + 3-amino-4-hydroxytoluene (95-84-1) → 2-acetamido-4-methylphenyl acetate (75813-74-0)

Guidance literature:

at 80 ℃; for 2h;

Reference yield: 93.0%

3-Methylacetanilide (537-92-8) + acetic acid (64-19-7,77671-22-8) → 2-acetamido-4-methylphenyl acetate (75813-74-0)

Guidance literature:

With potassium peroxomonosulphate; palladium diacetate; In 1,2-dichloro-ethane; at 100 ℃; for 48h;

DOI:10.1021/jo8003088

Reference yield:

4-methyl-2-nitrophenol (119-33-5) → 2-acetamido-4-methylphenyl acetate (75813-74-0)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH/KOH / Electrolysis_.Reduktion an Nickelkathode

2: sodium acetate

With potassium hydroxide; sodium hydroxide; sodium acetate;

upstream raw materials:

sodium acetate

acetic anhydride

3-amino-4-hydroxytoluene

4-methyl-2-nitrophenol

Downstream raw materials:

2-acetylamino-p-cresol

Refernces

• 1、 Wang, Guan-Wu,Yuan, Ting-Ting,Wu, Xue-Liang. "Direct ortho-acetoxylation of anilides via palladium-catalyzed sp 2 C-H bond oxidative activation". . p. 4717 - 4720. Retrieved 2008/09/21.