methyl (S)-3-{[(tert-butoxy)carbonyl]amino}-4-[1-(triphenylmetyl)-1H-imidazol-4-yl]butanoate

Base Information

Chemical Name:methyl (S)-3-{[(tert-butoxy)carbonyl]amino}-4-[1-(triphenylmetyl)-1H-imidazol-4-yl]butanoate
CAS No.:847153-38-2
Molecular Formula:C₃₂H₃₅N₃O₄
Molecular Weight:525.648
Hs Code.:

Synonyms:methyl (S)-3-{[(tert-butoxy)carbonyl]amino}-4-[1-(triphenylmetyl)-1H-imidazol-4-yl]butanoate

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Chemical Property of methyl (S)-3-{[(tert-butoxy)carbonyl]amino}-4-[1-(triphenylmetyl)-1H-imidazol-4-yl]butanoate

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Technology Process of methyl (S)-3-{[(tert-butoxy)carbonyl]amino}-4-[1-(triphenylmetyl)-1H-imidazol-4-yl]butanoate

There total 3 articles about methyl (S)-3-{[(tert-butoxy)carbonyl]amino}-4-[1-(triphenylmetyl)-1H-imidazol-4-yl]butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 76-83-5
trityl chloride

: 646068-74-8
methyl (S)-3-{[(tert-butoxy)carbonyl]amino}-4-(1H-imidazol-4-yl)butanoate

: 847153-38-2
methyl (S)-3-{[(tert-butoxy)carbonyl]amino}-4-[1-(triphenylmetyl)-1H-imidazol-4-yl]butanoate

Guidance literature:: With triethylamine; In chloroform;
DOI:10.1002/hlca.200390215

Reference yield:

: 35899-43-5
Boc-His(Tos)-OH

: 847153-38-2
methyl (S)-3-{[(tert-butoxy)carbonyl]amino}-4-[1-(triphenylmetyl)-1H-imidazol-4-yl]butanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: Et₃N; ClCO₂iBu / tetrahydrofuran / 0.5 h / -25 °C

1.2: 86 percent / tetrahydrofuran; diethyl ether / 0 - 20 °C

2.1: CF₃CO₂Ag; Et₃N / -25 - 20 °C

2.2: 91 percent / Ac₂O / pyridine

3.1: 100 percent / Et₃N / CHCl₃ / 55 h / 0 - 20 °C

With silver trifluoroacetate; triethylamine; isobutyl chloroformate; In tetrahydrofuran; chloroform; 2.1: Wolf-rearrangement;
DOI:10.1002/hlca.200490280

Reference yield:

: 847153-37-1
(S)-3-{[(tert-butoxy)carbonyl]amino}-1-diazo-4-{1-[(4-methylphenyl)sulfonyl]-1H-imidazol-4-yl}butan-2-one

: 847153-38-2
methyl (S)-3-{[(tert-butoxy)carbonyl]amino}-4-[1-(triphenylmetyl)-1H-imidazol-4-yl]butanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: CF₃CO₂Ag; Et₃N / -25 - 20 °C

1.2: 91 percent / Ac₂O / pyridine

2.1: 100 percent / Et₃N / CHCl₃ / 55 h / 0 - 20 °C

With silver trifluoroacetate; triethylamine; In chloroform; 1.1: Wolf-rearrangement;
DOI:10.1002/hlca.200490280