ethyl 4-oxo-2-(6-(4-(trifluoromethoxy)phenyl)pyridin-3-yl)-1,4-dihydroquinoline-3-carboxylate

Base Information

Chemical Name:ethyl 4-oxo-2-(6-(4-(trifluoromethoxy)phenyl)pyridin-3-yl)-1,4-dihydroquinoline-3-carboxylate
CAS No.:1374403-01-6
Molecular Formula:C₂₄H₁₇F₃N₂O₄
Molecular Weight:454.405
Hs Code.:

Synonyms:ethyl 4-oxo-2-(6-(4-(trifluoromethoxy)phenyl)pyridin-3-yl)-1,4-dihydroquinoline-3-carboxylate

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Chemical Property of ethyl 4-oxo-2-(6-(4-(trifluoromethoxy)phenyl)pyridin-3-yl)-1,4-dihydroquinoline-3-carboxylate

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Technology Process of ethyl 4-oxo-2-(6-(4-(trifluoromethoxy)phenyl)pyridin-3-yl)-1,4-dihydroquinoline-3-carboxylate

There total 5 articles about ethyl 4-oxo-2-(6-(4-(trifluoromethoxy)phenyl)pyridin-3-yl)-1,4-dihydroquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 118-48-9
isatoic anhydride

: 1379615-69-6
(Z)-ethyl 3-hydroxy-3-(6-(4-(trifluoromethoxy)phenyl)pyridin-3-yl)acrylate

: 1374403-01-6
ethyl 4-oxo-2-(6-(4-(trifluoromethoxy)phenyl)pyridin-3-yl)-1,4-dihydroquinoline-3-carboxylate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Inert atmosphere; Reflux;
DOI:10.1021/jm201184h

Reference yield: 28.0%

: 1374403-01-6
ethyl 4-oxo-2-(6-(4-(trifluoromethoxy)phenyl)pyridin-3-yl)-1,4-dihydroquinoline-3-carboxylate

Guidance literature:

Reference yield:

: 851069-97-1
6-(4-(trifluoromethoxy)phenyl)nicotinaldehyde

: 1374403-01-6
ethyl 4-oxo-2-(6-(4-(trifluoromethoxy)phenyl)pyridin-3-yl)-1,4-dihydroquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: niobium pentachloride / dichloromethane / 20 °C / Inert atmosphere

2: sodium hydride / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere; Reflux

With niobium pentachloride; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm201184h