N₃-(6-nitro-1,3-benzothiazol-2-yl)-2-(3-chloro-4-fluoroanilino)nicotinamide

Base Information

Chemical Name:N₃-(6-nitro-1,3-benzothiazol-2-yl)-2-(3-chloro-4-fluoroanilino)nicotinamide
CAS No.:1350515-67-1
Molecular Formula:C₁₉H₁₁ClFN₅O₃S
Molecular Weight:443.845
Hs Code.:

N<sub>3</sub>-(6-nitro-1,3-benzothiazol-2-yl)-2-(3-chloro-4-fluoroanilino)nicotinamide

Synonyms:N₃-(6-nitro-1,3-benzothiazol-2-yl)-2-(3-chloro-4-fluoroanilino)nicotinamide

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Chemical Property of N₃-(6-nitro-1,3-benzothiazol-2-yl)-2-(3-chloro-4-fluoroanilino)nicotinamide

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Technology Process of N₃-(6-nitro-1,3-benzothiazol-2-yl)-2-(3-chloro-4-fluoroanilino)nicotinamide

There total 4 articles about N₃-(6-nitro-1,3-benzothiazol-2-yl)-2-(3-chloro-4-fluoroanilino)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 6285-57-0
2-amino-6-nitrobenzothiazole

: 1293248-61-9
C₁₂H₈ClFN₂O₂

: 1350515-67-1
N₃-(6-nitro-1,3-benzothiazol-2-yl)-2-(3-chloro-4-fluoroanilino)nicotinamide

Guidance literature:: C₁₂H₈ClFN₂O₂; With benzotriazol-1-ol; In N,N-dimethyl-formamide; at 0 ℃; for 0.166667h;

2-amino-6-nitrobenzothiazole; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 8h;
DOI:10.1016/j.bmc.2011.09.060

Reference yield:

: 367-22-6
4-chloro-3-fluoroaniline

: 1350515-67-1
N₃-(6-nitro-1,3-benzothiazol-2-yl)-2-(3-chloro-4-fluoroanilino)nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethylene glycol / 6 h / 160 °C

2.1: sodium hydroxide / ethanol / 2 h / Reflux

3.1: benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h / 0 °C

3.2: 8 h / 20 °C

With benzotriazol-1-ol; sodium hydroxide; In ethanol; ethylene glycol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.09.060

Reference yield:

: 1350515-52-4
C₁₄H₁₂ClFN₂O₂

: 1350515-67-1
N₃-(6-nitro-1,3-benzothiazol-2-yl)-2-(3-chloro-4-fluoroanilino)nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / ethanol / 2 h / Reflux

2.1: benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h / 0 °C

2.2: 8 h / 20 °C

With benzotriazol-1-ol; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.09.060