2-[N-(4-phenylbenzenecarbonyl)amino]-6-(trans-2-phenylcyclopropane-1-amino)-N-(3-phenylbenzyl)hexanamide trifluoroacetate

Base Information

Chemical Name:2-[N-(4-phenylbenzenecarbonyl)amino]-6-(trans-2-phenylcyclopropane-1-amino)-N-(3-phenylbenzyl)hexanamide trifluoroacetate
CAS No.:1456907-32-6
Molecular Formula:C₂HF₃O₂*C₄₁H₄₁N₃O₂
Molecular Weight:721.819
Hs Code.:

Synonyms:2-[N-(4-phenylbenzenecarbonyl)amino]-6-(trans-2-phenylcyclopropane-1-amino)-N-(3-phenylbenzyl)hexanamide trifluoroacetate

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Chemical Property of 2-[N-(4-phenylbenzenecarbonyl)amino]-6-(trans-2-phenylcyclopropane-1-amino)-N-(3-phenylbenzyl)hexanamide trifluoroacetate

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Technology Process of 2-[N-(4-phenylbenzenecarbonyl)amino]-6-(trans-2-phenylcyclopropane-1-amino)-N-(3-phenylbenzyl)hexanamide trifluoroacetate

There total 8 articles about 2-[N-(4-phenylbenzenecarbonyl)amino]-6-(trans-2-phenylcyclopropane-1-amino)-N-(3-phenylbenzyl)hexanamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 2-amino-6-(trans-2-phenylcyclopropane-1-amino)-N-(3-phenylbenzyl)hexanamide dihydrochloride

: 76-05-1
trifluoroacetic acid

: 92-92-2
biphenyl-4-carboxylic acid

: 1456907-32-6
2-[N-(4-phenylbenzenecarbonyl)amino]-6-(trans-2-phenylcyclopropane-1-amino)-N-(3-phenylbenzyl)hexanamide trifluoroacetate

Guidance literature:: 2-amino-6-(trans-2-phenylcyclopropane-1-amino)-N-(3-phenylbenzyl)hexanamide dihydrochloride; biphenyl-4-carboxylic acid; With dmap; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃;

trifluoroacetic acid; In water;
DOI:10.1002/anie.201303999

Reference yield:

: 2389-45-9
Boc-Lys(Z)-OH

: 1456907-32-6
2-[N-(4-phenylbenzenecarbonyl)amino]-6-(trans-2-phenylcyclopropane-1-amino)-N-(3-phenylbenzyl)hexanamide trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C

2: 5%-palladium/activated carbon; hydrogen / methanol / 20 °C

3: hydrogenchloride; sodium nitrite; acetic acid / 1,4-dioxane; water; acetonitrile / 0 - 20 °C

4: triethylamine; dmap / dichloromethane / 0 - 20 °C

5: potassium carbonate / N,N-dimethyl-formamide / 50 - 55 °C

6: hydrogenchloride / 1,4-dioxane; dichloromethane / 0 - 20 °C

7: dmap; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; dmap; 5%-palladium/activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium nitrite; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/anie.201303999

Reference yield:

: 177976-49-7
3-phenylbenzylamine

: 1456907-32-6
2-[N-(4-phenylbenzenecarbonyl)amino]-6-(trans-2-phenylcyclopropane-1-amino)-N-(3-phenylbenzyl)hexanamide trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C

2: 5%-palladium/activated carbon; hydrogen / methanol / 20 °C

3: hydrogenchloride; sodium nitrite; acetic acid / 1,4-dioxane; water; acetonitrile / 0 - 20 °C

4: triethylamine; dmap / dichloromethane / 0 - 20 °C

5: potassium carbonate / N,N-dimethyl-formamide / 50 - 55 °C

6: hydrogenchloride / 1,4-dioxane; dichloromethane / 0 - 20 °C

7: dmap; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; dmap; 5%-palladium/activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium nitrite; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/anie.201303999