(Z)-7-{(1S,2R,3aR,4R,7R,7aS,8S)-1-[(E)-(S)-3-(tert-Butyl-diphenyl-silanyloxy)-oct-1-enyl]-4,5,6,7,8-pentamethyl-3-oxo-2,3,3a,4,7,7a-hexahydro-1H-4,7-methano-inden-2-yl}-hept-5-enoic acid

Base Information

Chemical Name:(Z)-7-{(1S,2R,3aR,4R,7R,7aS,8S)-1-[(E)-(S)-3-(tert-Butyl-diphenyl-silanyloxy)-oct-1-enyl]-4,5,6,7,8-pentamethyl-3-oxo-2,3,3a,4,7,7a-hexahydro-1H-4,7-methano-inden-2-yl}-hept-5-enoic acid
CAS No.:129944-68-9
Molecular Formula:C₄₆H₆₄O₄Si
Molecular Weight:709.097
Hs Code.:

(Z)-7-{(1S,2R,3aR,4R,7R,7aS,8S)-1-[(E)-(S)-3-(tert-Butyl-diphenyl-silanyloxy)-oct-1-enyl]-4,5,6,7,8-pentamethyl-3-oxo-2,3,3a,4,7,7a-hexahydro-1H-4,7-methano-inden-2-yl}-hept-5-enoic acid

Synonyms:(Z)-7-{(1S,2R,3aR,4R,7R,7aS,8S)-1-[(E)-(S)-3-(tert-Butyl-diphenyl-silanyloxy)-oct-1-enyl]-4,5,6,7,8-pentamethyl-3-oxo-2,3,3a,4,7,7a-hexahydro-1H-4,7-methano-inden-2-yl}-hept-5-enoic acid

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Chemical Property of (Z)-7-{(1S,2R,3aR,4R,7R,7aS,8S)-1-[(E)-(S)-3-(tert-Butyl-diphenyl-silanyloxy)-oct-1-enyl]-4,5,6,7,8-pentamethyl-3-oxo-2,3,3a,4,7,7a-hexahydro-1H-4,7-methano-inden-2-yl}-hept-5-enoic acid

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Technology Process of (Z)-7-{(1S,2R,3aR,4R,7R,7aS,8S)-1-[(E)-(S)-3-(tert-Butyl-diphenyl-silanyloxy)-oct-1-enyl]-4,5,6,7,8-pentamethyl-3-oxo-2,3,3a,4,7,7a-hexahydro-1H-4,7-methano-inden-2-yl}-hept-5-enoic acid

There total 9 articles about (Z)-7-{(1S,2R,3aR,4R,7R,7aS,8S)-1-[(E)-(S)-3-(tert-Butyl-diphenyl-silanyloxy)-oct-1-enyl]-4,5,6,7,8-pentamethyl-3-oxo-2,3,3a,4,7,7a-hexahydro-1H-4,7-methano-inden-2-yl}-hept-5-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 129944-67-8,130009-12-0
(3aS,4R,7R,7aR,8S)-4,5,6,7,8-Pentamethyl-3a,4,7,7a-tetrahydro-4,7-methano-inden-1-one

: 129944-68-9
(Z)-7-{(1S,2R,3aR,4R,7R,7aS,8S)-1-[(E)-(S)-3-(tert-Butyl-diphenyl-silanyloxy)-oct-1-enyl]-4,5,6,7,8-pentamethyl-3-oxo-2,3,3a,4,7,7a-hexahydro-1H-4,7-methano-inden-2-yl}-hept-5-enoic acid

Guidance literature:: Multi-step reaction with 3 steps

2: LiOH / methanol; tetrahydrofuran / 10 h / 55 °C

With lithium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1039/c39900000410

Reference yield:

: 101126-09-4,101222-44-0
(1S,4R,4aR,8aS,9S)-1,2,3,4,9-Pentamethyl-1,4,4a,8a-tetrahydro-1,4-methano-naphthalene-5,8-dione

: 129944-68-9
(Z)-7-{(1S,2R,3aR,4R,7R,7aS,8S)-1-[(E)-(S)-3-(tert-Butyl-diphenyl-silanyloxy)-oct-1-enyl]-4,5,6,7,8-pentamethyl-3-oxo-2,3,3a,4,7,7a-hexahydro-1H-4,7-methano-inden-2-yl}-hept-5-enoic acid

Guidance literature:: Multi-step reaction with 9 steps

1: 30percent H₂O₂, Na₂CO₃ / acetone / 1.5 h / 0 °C

2: 74 percent / MeONa / 1.5 h / 45 °C

3: 92 percent / KOH/MeOH / 17 h / 50 °C

5: oxalyl chloride / CHCl₃

6: t-butyl mercaptan, 4-dimethylaminopyridine / benzene / 60 °C

8: LiOH / methanol; tetrahydrofuran / 10 h / 55 °C

With methanol; dmap; potassium hydroxide; lithium hydroxide; oxalyl dichloride; dihydrogen peroxide; sodium methylate; sodium carbonate; 2-methylpropan-2-thiol; In tetrahydrofuran; methanol; chloroform; acetone; benzene;
DOI:10.1039/c39900000410

Reference yield:

: (3aR,4R,7R,7aS,8R)-4,5,6,7,8-Pentamethyl-1-oxo-1,4,7,7a-tetrahydro-4,7-methano-indene-3a-carbonyl chloride

: 129944-68-9
(Z)-7-{(1S,2R,3aR,4R,7R,7aS,8S)-1-[(E)-(S)-3-(tert-Butyl-diphenyl-silanyloxy)-oct-1-enyl]-4,5,6,7,8-pentamethyl-3-oxo-2,3,3a,4,7,7a-hexahydro-1H-4,7-methano-inden-2-yl}-hept-5-enoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: t-butyl mercaptan, 4-dimethylaminopyridine / benzene / 60 °C

3: LiOH / methanol; tetrahydrofuran / 10 h / 55 °C

With dmap; lithium hydroxide; 2-methylpropan-2-thiol; In tetrahydrofuran; methanol; benzene;
DOI:10.1039/c39900000410