ethyl (3R,4R)-3-benzylamino-2,2-difluoro-4,5-O-isopropylidenepentanoate

Base Information

Chemical Name:ethyl (3R,4R)-3-benzylamino-2,2-difluoro-4,5-O-isopropylidenepentanoate
CAS No.:147633-27-0
Molecular Formula:C₁₇H₂₃F₂NO₄
Molecular Weight:343.371
Hs Code.:

Synonyms:ethyl (3R,4R)-3-benzylamino-2,2-difluoro-4,5-O-isopropylidenepentanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl (3R,4R)-3-benzylamino-2,2-difluoro-4,5-O-isopropylidenepentanoate

Chemical Property:

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Technology Process of ethyl (3R,4R)-3-benzylamino-2,2-difluoro-4,5-O-isopropylidenepentanoate

There total 3 articles about ethyl (3R,4R)-3-benzylamino-2,2-difluoro-4,5-O-isopropylidenepentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 667-27-6
Ethyl bromodifluoroacetate

: 135821-68-0
(S)-N-benzyl-2,3-O-isopropylidene-glyceraldimine

: 135777-60-5
(4R)-1-benzyl-3,3-difluoro-4-<(4'R)-2',2'-dimethyl-1',3'-dioxolan>-azetidin-2-one

: 147633-26-9
(S)-1-Benzyl-4-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3,3-difluoro-azetidin-2-one

: 147633-27-0
ethyl (3R,4R)-3-benzylamino-2,2-difluoro-4,5-O-isopropylidenepentanoate

Guidance literature:: With zinc; In tetrahydrofuran; for 1h; Heating;
DOI:10.1016/S0040-4020(01)82003-2

Reference yield:

: 100-46-9
benzylamine

: 147633-27-0
ethyl (3R,4R)-3-benzylamino-2,2-difluoro-4,5-O-isopropylidenepentanoate

Guidance literature:: Multi-step reaction with 2 steps

2: 22 percent / activated Zn / tetrahydrofuran / 1 h / Heating

With zinc; In tetrahydrofuran;
DOI:10.1016/S0040-4020(01)82003-2

Reference yield:

: 22323-80-4
(4S)-2,2-dimethyl-[1,3]dioxolane-4-carbaldehyde

: 147633-27-0
ethyl (3R,4R)-3-benzylamino-2,2-difluoro-4,5-O-isopropylidenepentanoate

Guidance literature:: Multi-step reaction with 2 steps

2: 22 percent / activated Zn / tetrahydrofuran / 1 h / Heating

With zinc; In tetrahydrofuran;
DOI:10.1016/S0040-4020(01)82003-2