2-(2-hydroxy-2-methylpropylamino)-4-(3-methyl-4-quinolin-3-ylindazol-1-yl)benzamide

Base Information

Chemical Name:2-(2-hydroxy-2-methylpropylamino)-4-(3-methyl-4-quinolin-3-ylindazol-1-yl)benzamide
CAS No.:1246306-72-8
Molecular Formula:C₂₈H₂₇N₅O₂
Molecular Weight:465.555
Hs Code.:

Synonyms:2-(2-hydroxy-2-methylpropylamino)-4-(3-methyl-4-quinolin-3-ylindazol-1-yl)benzamide

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Chemical Property of 2-(2-hydroxy-2-methylpropylamino)-4-(3-methyl-4-quinolin-3-ylindazol-1-yl)benzamide

Chemical Property:

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Technology Process of 2-(2-hydroxy-2-methylpropylamino)-4-(3-methyl-4-quinolin-3-ylindazol-1-yl)benzamide

There total 6 articles about 2-(2-hydroxy-2-methylpropylamino)-4-(3-methyl-4-quinolin-3-ylindazol-1-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1246306-73-9
2-(2-hydroxy-2-methylpropylamino)-4-(3-methyl-4-quinolin-3-ylindazol-1-yl)benzonitrile

: 1246306-72-8
2-(2-hydroxy-2-methylpropylamino)-4-(3-methyl-4-quinolin-3-ylindazol-1-yl)benzamide

Guidance literature:: With water; dihydrogen peroxide; sodium hydroxide; In ethanol; dimethyl sulfoxide; at 20 ℃; for 0.75h; Inert atmosphere;

Reference yield:

: 848678-69-3
trifluoromethanesulphonic acid 3-methyl-1H-indazol-4-yl ester

: 1246306-72-8
2-(2-hydroxy-2-methylpropylamino)-4-(3-methyl-4-quinolin-3-ylindazol-1-yl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 1 h / 90 °C / Inert atmosphere

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C / Inert atmosphere

3: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 3.5 h / 90 °C / Inert atmosphere

4: water; dihydrogen peroxide; sodium hydroxide / ethanol; dimethyl sulfoxide / 0.75 h / 20 °C / Inert atmosphere

With water; dihydrogen peroxide; sodium hydride; sodium carbonate; caesium carbonate; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 149071-05-6
3-methyl-4-hydroxyindazole

: 1246306-72-8
2-(2-hydroxy-2-methylpropylamino)-4-(3-methyl-4-quinolin-3-ylindazol-1-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / tetrahydrofuran; dichloromethane / 20 °C / Inert atmosphere

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 1 h / 90 °C / Inert atmosphere

3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C / Inert atmosphere

4: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 3.5 h / 90 °C / Inert atmosphere

5: water; dihydrogen peroxide; sodium hydroxide / ethanol; dimethyl sulfoxide / 0.75 h / 20 °C / Inert atmosphere

With water; dihydrogen peroxide; sodium hydride; sodium carbonate; caesium carbonate; triethylamine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; mineral oil;