N-({2-[2-(1,1-dimethylethyl)phenyl]-6-hydroxy-5-quinoxalinyl}carbonyl)glycine

Base Information

Chemical Name:N-({2-[2-(1,1-dimethylethyl)phenyl]-6-hydroxy-5-quinoxalinyl}carbonyl)glycine
CAS No.:1160685-53-9
Molecular Formula:C₂₁H₂₁N₃O₄
Molecular Weight:379.415
Hs Code.:

Synonyms:N-({2-[2-(1,1-dimethylethyl)phenyl]-6-hydroxy-5-quinoxalinyl}carbonyl)glycine

Suppliers and Price of N-({2-[2-(1,1-dimethylethyl)phenyl]-6-hydroxy-5-quinoxalinyl}carbonyl)glycine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-({2-[2-(1,1-dimethylethyl)phenyl]-6-hydroxy-5-quinoxalinyl}carbonyl)glycine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-({2-[2-(1,1-dimethylethyl)phenyl]-6-hydroxy-5-quinoxalinyl}carbonyl)glycine

There total 9 articles about N-({2-[2-(1,1-dimethylethyl)phenyl]-6-hydroxy-5-quinoxalinyl}carbonyl)glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.1%

: 1160682-32-5
ethyl N-[(2-bromo-6-hydroxy-5-quinoxalinyl)carbonyl]glycinate

: 89787-13-3
(2-(tert-butyl)phenyl)boronic acid

: 1160685-53-9
N-({2-[2-(1,1-dimethylethyl)phenyl]-6-hydroxy-5-quinoxalinyl}carbonyl)glycine

Guidance literature:: ethyl N-[(2-bromo-6-hydroxy-5-quinoxalinyl)carbonyl]glycinate; (2-(tert-butyl)phenyl)boronic acid; With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 120 ℃; for 1h; Inert atmosphere; Microwave irradiation;

With water; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; at 20 ℃; for 0.166667h;

With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

: 13671-00-6
methyl 2,6-difluorobenzoate

: 1160685-53-9
N-({2-[2-(1,1-dimethylethyl)phenyl]-6-hydroxy-5-quinoxalinyl}carbonyl)glycine

Guidance literature:: Multi-step reaction with 9 steps

1.1: sulfuric acid; nitric acid / 0 - 20 °C

2.1: ammonium hydroxide / ethanol; water / 20 °C

3.1: sodium hydride / mineral oil / 1 h / 0 - 20 °C

4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2585.81 Torr

5.1: toluene; acetonitrile / 0.25 h / 20 °C

6.1: trichlorophosphate / Reflux

7.1: boron tribromide / dichloromethane / 20 °C

8.1: triethylamine; HATU / N,N-dimethyl-formamide

9.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 120 °C / Inert atmosphere; Microwave irradiation

9.2: 0.17 h / 20 °C

With ammonium hydroxide; sulfuric acid; hydrogen; nitric acid; boron tribromide; sodium hydride; potassium carbonate; triethylamine; HATU; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In 1,4-dioxane; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;

Reference yield:

: 1160682-17-6
methyl 2,3-diamino-6-methoxybenzoate

: 1160685-53-9
N-({2-[2-(1,1-dimethylethyl)phenyl]-6-hydroxy-5-quinoxalinyl}carbonyl)glycine

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene; acetonitrile / 0.25 h / 20 °C

2.1: trichlorophosphate / Reflux

3.1: boron tribromide / dichloromethane / 20 °C

4.1: triethylamine; HATU / N,N-dimethyl-formamide

5.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 120 °C / Inert atmosphere; Microwave irradiation

5.2: 0.17 h / 20 °C

With boron tribromide; potassium carbonate; triethylamine; HATU; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;