ethyl (2R^*,3S^*)-3-hexyl-1-(4-tolylsulfonyl)aziridine-2-carboxylate

Base Information

• Chemical Name: ethyl (2R^*,3S^*)-3-hexyl-1-(4-tolylsulfonyl)aziridine-2-carboxylate
• CAS No.: 140241-30-1
• Molecular Formula: C₁₈H₂₇NO₄S
• Molecular Weight: 353.483
• Mol file: 140241-30-1.mol

Synonyms:ethyl (2R^*,3S^*)-3-hexyl-1-(4-tolylsulfonyl)aziridine-2-carboxylate

Chemical Property of ethyl (2R^*,3S^*)-3-hexyl-1-(4-tolylsulfonyl)aziridine-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (2R^*,3S^*)-3-hexyl-1-(4-tolylsulfonyl)aziridine-2-carboxylate

There total 1 articles about ethyl (2R^*,3S^*)-3-hexyl-1-(4-tolylsulfonyl)aziridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

Ethyl trans-3-hexylaziridine-2-carboxylate (139618-67-0,140241-22-1) + p-toluenesulfonyl chloride (98-59-9) → ethyl (2R*,3S*)-3-hexyl-1-(4-tolylsulfonyl)aziridine-2-carboxylate (140241-30-1)

Guidance literature:

With dmap; triethylamine; In dichloromethane; 1.) 0 deg C, 30 min, 2.) RT, 2 h;

DOI:10.1016/0040-4020(96)00523-6

Reference yield: 93.0%

ethyl (2R*,3S*)-3-hexyl-1-(4-tolylsulfonyl)aziridine-2-carboxylate (140241-30-1) + acetonitrile (75-05-8,26809-02-9) → ethyl (4R*,5R*)-4-hexyl-2-methyl-1-(4-tolylsulfonyl)imidazoline-5-carboxylate (140241-65-2)

Guidance literature:

With boron trifluoride diethyl etherate; 0 deg C, 1 h, then r.t. for 2 h;

DOI:10.1002/recl.19921110201

Reference yield: 84.0%

ethyl (2R*,3S*)-3-hexyl-1-(4-tolylsulfonyl)aziridine-2-carboxylate (140241-30-1) → (2S,3R)-3-Hexyl-1-(toluene-4-sulfonyl)-aziridine-2-carbaldehyde

Guidance literature:

With diisobutylaluminium hydride; In hexane; dichloromethane; at -78 ℃; for 1h;

DOI:10.1016/0040-4020(96)00712-0

upstream raw materials:

Ethyl trans-3-hexylaziridine-2-carboxylate

p-toluenesulfonyl chloride

Downstream raw materials:

(2S,3S)-3-Formyloxy-2-(toluene-4-sulfonylamino)-nonanoic acid ethyl ester

ethyl (2R^*,3S^*)-3-(phenylthio)-2-<(4-tolylsulfonyl)amino>nonanoate

ethyl (2R^*,3S^*)-3-chloro-2-<(4-tolylsulfonyl)amino>nonanoate

ethyl (2R^*,3R^*)-2-chloro-3-<(4-tolylsulfonyl)amino>nonanoate