1-dimethylamino-8-methoxy-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]decane-2,4-dione

Base Information

Chemical Name:1-dimethylamino-8-methoxy-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]decane-2,4-dione
CAS No.:1309928-05-9
Molecular Formula:C₂₀H₂₉N₃O₃
Molecular Weight:359.469
Hs Code.:

Synonyms:1-dimethylamino-8-methoxy-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]decane-2,4-dione

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Chemical Property of 1-dimethylamino-8-methoxy-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]decane-2,4-dione

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Technology Process of 1-dimethylamino-8-methoxy-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]decane-2,4-dione

There total 5 articles about 1-dimethylamino-8-methoxy-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]decane-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1309928-03-7
4-{N',N'-dimethyl-N-[2-(2,4,6-trimethyl-phenyl)-acetyl]-hydrazino}-1-methoxy-piperidine-4-carboxylic acid methyl ester

: 1309928-05-9
1-dimethylamino-8-methoxy-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]decane-2,4-dione

Guidance literature:: 4-{N',N'-dimethyl-N-[2-(2,4,6-trimethyl-phenyl)-acetyl]-hydrazino}-1-methoxy-piperidine-4-carboxylic acid methyl ester; With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

With hydrogenchloride; In water; N,N-dimethyl-formamide; pH=4.9;

Reference yield:

: 1309928-00-4
N'-(1-methoxy-piperidin-4-ylidene)-N,N-dimethyl-hydrazine

: 1309928-05-9
1-dimethylamino-8-methoxy-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]decane-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: water / 15 - 20 °C

2.1: dmap; pyridine / tetrahydrofuran / 18 h / 20 °C

3.1: sulfuric acid / 5 h / Reflux

3.2: pH 5 / Cooling with ice

4.1: potassium tert-butylate / N,N-dimethyl-formamide / 18 h / 20 °C

4.2: pH 4.9

With pyridine; dmap; sulfuric acid; potassium tert-butylate; water; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 102170-24-1
1-methoxypiperidin-4-one

: 1309928-05-9
1-dimethylamino-8-methoxy-3-(2,4,6-trimethyl-phenyl)-1,8-diaza-spiro[4.5]decane-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: 18 h / 20 °C / Cooling with ice

2.1: water / 15 - 20 °C

3.1: dmap; pyridine / tetrahydrofuran / 18 h / 20 °C

4.1: sulfuric acid / 5 h / Reflux

4.2: pH 5 / Cooling with ice

5.1: potassium tert-butylate / N,N-dimethyl-formamide / 18 h / 20 °C

5.2: pH 4.9

With pyridine; dmap; sulfuric acid; potassium tert-butylate; water; In tetrahydrofuran; N,N-dimethyl-formamide;