N-{2-chloro-3-[5-(4-pyrimidinyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-2,6-difluorobenzenesulfonamide

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Chemical Name:N-{2-chloro-3-[5-(4-pyrimidinyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-2,6-difluorobenzenesulfonamide
CAS No.:1195764-97-6
Molecular Formula:C₂₄H₁₉ClF₂N₄O₃S₂
Molecular Weight:549.022
Hs Code.:

Synonyms:N-{2-chloro-3-[5-(4-pyrimidinyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-2,6-difluorobenzenesulfonamide

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Chemical Property of N-{2-chloro-3-[5-(4-pyrimidinyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-2,6-difluorobenzenesulfonamide

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Technology Process of N-{2-chloro-3-[5-(4-pyrimidinyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-2,6-difluorobenzenesulfonamide

There total 3 articles about N-{2-chloro-3-[5-(4-pyrimidinyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-2,6-difluorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.3%

: 1195768-63-8
N-{2-chloro-3-[5-(2-chloro-4-pyrimidinyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-2,6-difluorobenzenesulfonamide

: 1195764-97-6
N-{2-chloro-3-[5-(4-pyrimidinyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-2,6-difluorobenzenesulfonamide

Guidance literature:: With ammonium formate; 20 % Pd(OH)2/C; In methanol; ethyl acetate; at 60 ℃; for 2h;

Reference yield:

: 344329-76-6
tetrahydro-pyran-4-carboxylic acid amide

: 1195764-97-6
N-{2-chloro-3-[5-(4-pyrimidinyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-2,6-difluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: Lawessons reagent / tetrahydrofuran / 6 h / Reflux

2.1: N-Bromosuccinimide / N,N-dimethyl acetamide / 20 °C / Cooling with ice

2.2: 20 - 65 °C

3.1: ammonium formate / 20 % Pd(OH)2/C / methanol; ethyl acetate / 2 h / 60 °C

With Lawessons reagent; N-Bromosuccinimide; ammonium formate; 20 % Pd(OH)2/C; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; ethyl acetate;

Reference yield:

: 88571-77-1
tetrahydro-2H-pyran-4-carbothioamide

: 1195764-97-6
N-{2-chloro-3-[5-(4-pyrimidinyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-2,6-difluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide / N,N-dimethyl acetamide / 20 °C / Cooling with ice

1.2: 20 - 65 °C

2.1: ammonium formate / 20 % Pd(OH)2/C / methanol; ethyl acetate / 2 h / 60 °C

With N-Bromosuccinimide; ammonium formate; 20 % Pd(OH)2/C; In methanol; N,N-dimethyl acetamide; ethyl acetate;