5-BROMO-2-ETHYNYL-THIOPHENE

Base Information

• Chemical Name: 5-BROMO-2-ETHYNYL-THIOPHENE
• CAS No.: 105995-73-1
• Molecular Formula: C6H3 Br S
• Molecular Weight: 187.06
• Hs Code.: 2934999090
• Mol file: 105995-73-1.mol

Synonyms:(5-Bromothien-2-yl)acetylene

Chemical Property of 5-BROMO-2-ETHYNYL-THIOPHENE

Chemical Property:

• PSA: 28.24000
• LogP: 2.49190
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-5-ethynylthiophene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BROMO-2-ETHYNYL-THIOPHENE

There total 3 articles about 5-BROMO-2-ETHYNYL-THIOPHENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

5-bromo-2-thiophencarboxaldehyde (4701-17-1) + dimethyl 1-(1-diazo-2-oxopropyl)phosphonate (90965-06-3) → 2-bromo-5-ethynyl thiophene (105995-73-1)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 12h;

DOI:10.1016/j.ejmech.2019.06.049

Reference yield: 92.0%

→ 2-bromo-5-ethynyl thiophene (105995-73-1)

Guidance literature:

With dimethyl 1-(1-diazo-2-oxopropyl)phosphonate; potassium carbonate; In methanol; at 20 ℃; for 12h;

Reference yield:

((5-bromothiophene-2-yl)ethynyl)trimethylsilane (606925-57-9) → 2-bromo-5-ethynyl thiophene (105995-73-1)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 1h;

DOI:10.1021/ol0478180

upstream raw materials:

((5-bromothiophene-2-yl)ethynyl)trimethylsilane

5-bromo-2-thiophencarboxaldehyde

dimethyl 1-(1-diazo-2-oxopropyl)phosphonate

Refernces

• 1、 -. "1,4-DISUBSTITUTED 1,2,3-TRIAZOLES, METHODS FOR PREPARING SAME, AND DIAGNOSTIC AND THERAPEUTIC USES THEREOF". Paragraph 0429; 0430; 0431; 0432; 0434. . Retrieved 2014/02/16.