Technology Process of (3R,4R,6R)-3-benzoyloxymethyl-1-tert-butyldiphenylsiloxy-6,7-isopropylidenedioxy-3,4-heptanediol
There total 7 articles about (3R,4R,6R)-3-benzoyloxymethyl-1-tert-butyldiphenylsiloxy-6,7-isopropylidenedioxy-3,4-heptanediol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium dioxotetrahydroxoosmate(VI); methanesulfonamide; 1,4-bis(9-O-dihydroquinidine)phthalazine;
potassium carbonate; potassium hexacyanoferrate(III);
In
water; tert-butyl alcohol;
at 20 ℃;
DOI:10.1016/j.tetlet.2007.03.152
- Guidance literature:
-
Multi-step reaction with 5 steps
1: DIBAlH / toluene / 0.33 h / -78 °C
2: imidazole / dimethylformamide / 0.5 h / 20 °C
3: NaBH4; CeCl3*7H2O / methanol / 0.25 h / -78 °C
4: Et3N / CH2Cl2 / 1 h / 0 °C
5: 91 percent / (DHQD)2PHAL; K2OsO2(OH)4; MeSO2NH2 / K3Fe(CN)6; K2CO3 / 2-methyl-propan-2-ol; H2O / 20 °C
With
1H-imidazole; sodium tetrahydroborate; cerium(III) chloride; potassium dioxotetrahydroxoosmate(VI); methanesulfonamide; diisobutylaluminium hydride; 1,4-bis(9-O-dihydroquinidine)phthalazine; triethylamine;
potassium carbonate; potassium hexacyanoferrate(III);
In
methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;
5: Sharpless asymmetric dihydroxylation;
DOI:10.1016/j.tetlet.2007.03.152
- Guidance literature:
-
Multi-step reaction with 4 steps
1: imidazole / dimethylformamide / 0.5 h / 20 °C
2: NaBH4; CeCl3*7H2O / methanol / 0.25 h / -78 °C
3: Et3N / CH2Cl2 / 1 h / 0 °C
4: 91 percent / (DHQD)2PHAL; K2OsO2(OH)4; MeSO2NH2 / K3Fe(CN)6; K2CO3 / 2-methyl-propan-2-ol; H2O / 20 °C
With
1H-imidazole; sodium tetrahydroborate; cerium(III) chloride; potassium dioxotetrahydroxoosmate(VI); methanesulfonamide; 1,4-bis(9-O-dihydroquinidine)phthalazine; triethylamine;
potassium carbonate; potassium hexacyanoferrate(III);
In
methanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
4: Sharpless asymmetric dihydroxylation;
DOI:10.1016/j.tetlet.2007.03.152