1,1-dimethylethyl {1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-3-piperidinyl}carbamate

Base Information

Chemical Name:1,1-dimethylethyl {1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-3-piperidinyl}carbamate
CAS No.:1227911-10-5
Molecular Formula:C₂₁H₂₈N₈O₂
Molecular Weight:424.506
Hs Code.:

Synonyms:1,1-dimethylethyl {1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-3-piperidinyl}carbamate

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Chemical Property of 1,1-dimethylethyl {1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-3-piperidinyl}carbamate

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Technology Process of 1,1-dimethylethyl {1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-3-piperidinyl}carbamate

There total 1 articles about 1,1-dimethylethyl {1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-3-piperidinyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 184637-48-7,172603-05-3
t-butyl piperidin-3-ylcarbamate

: 1227911-10-5
1,1-dimethylethyl {1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-3-piperidinyl}carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: methanol; ethanol / 50 - 100 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / 1,4-dioxane; water / 95 °C

3: hydrazine hydrate / ethanol / 80 - 100 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; hydrazine hydrate; In 1,4-dioxane; methanol; ethanol; water; 2: Suzuki coupling;
DOI:10.1021/jm101527u

Reference yield:

: 1227911-10-5
1,1-dimethylethyl {1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-3-piperidinyl}carbamate

: N-{1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-3-piperidinyl}benzamide dihydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / water / 0 - 20 °C

2.1: sodium hydrogencarbonate / tetrahydrofuran; water / 0 - 20 °C

2.2: 72 h / 65 °C

With hydrogenchloride; sodium hydrogencarbonate; In tetrahydrofuran; water;
DOI:10.1021/jm101527u

Reference yield:

: 1227911-10-5
1,1-dimethylethyl {1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-3-piperidinyl}carbamate

: 1227919-90-5
N-{1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-3-piperidinyl}benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / water / 0 - 20 °C

2.1: sodium hydrogencarbonate / tetrahydrofuran; water / 0 - 20 °C

2.2: 72 h / 65 °C

3.1: ammonium hydroxide / water; acetonitrile

With hydrogenchloride; ammonium hydroxide; sodium hydrogencarbonate; In tetrahydrofuran; water; acetonitrile;
DOI:10.1021/jm101527u