{1-[(S)-2-Carbamoyl-1-((S)-2-naphthalen-1-ylmethyl-pent-4-enylcarbamoyl)-ethylcarbamoyl]-1-methyl-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

Base Information

Chemical Name:{1-[(S)-2-Carbamoyl-1-((S)-2-naphthalen-1-ylmethyl-pent-4-enylcarbamoyl)-ethylcarbamoyl]-1-methyl-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester
CAS No.:495403-73-1
Molecular Formula:C₃₉H₄₂N₄O₅
Molecular Weight:646.786
Hs Code.:

{1-[(S)-2-Carbamoyl-1-((S)-2-naphthalen-1-ylmethyl-pent-4-enylcarbamoyl)-ethylcarbamoyl]-1-methyl-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

Synonyms:{1-[(S)-2-Carbamoyl-1-((S)-2-naphthalen-1-ylmethyl-pent-4-enylcarbamoyl)-ethylcarbamoyl]-1-methyl-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

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Chemical Property of {1-[(S)-2-Carbamoyl-1-((S)-2-naphthalen-1-ylmethyl-pent-4-enylcarbamoyl)-ethylcarbamoyl]-1-methyl-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

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Technology Process of {1-[(S)-2-Carbamoyl-1-((S)-2-naphthalen-1-ylmethyl-pent-4-enylcarbamoyl)-ethylcarbamoyl]-1-methyl-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

There total 1 articles about {1-[(S)-2-Carbamoyl-1-((S)-2-naphthalen-1-ylmethyl-pent-4-enylcarbamoyl)-ethylcarbamoyl]-1-methyl-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 94744-50-0
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-α-aminoisobutyric acid

: 401810-36-4
(2S)-2-amino-N¹-[(2S)-2-(naphthylmethyl)-4-pentenyl]butanediamide

: 495403-73-1
{1-[(S)-2-Carbamoyl-1-((S)-2-naphthalen-1-ylmethyl-pent-4-enylcarbamoyl)-ethylcarbamoyl]-1-methyl-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: With 1,3-di-tert-butylcarbodiimide; benzotriazol-1-ol; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm0203635

Reference yield:

: 495403-73-1
{1-[(S)-2-Carbamoyl-1-((S)-2-naphthalen-1-ylmethyl-pent-4-enylcarbamoyl)-ethylcarbamoyl]-1-methyl-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

: 2-[(1S,7S,11S,15S)-3,6,9-triaza-7-(carbamoylmethyl)-4,4-dimethyl-11-(naphthylmethyl)-2,5,8-trioxo-15-[4-(phosphonomethyl)phenyl]cyclopentadec-13-enyl]acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: piperidine / acetonitrile / 2 h / 20 °C

2: 75 percent / HOAt; EDCI / dimethylformamide / 20 °C

3: 83 percent / (PCy₃)2Cl₂Ru=CHPh / CH₂Cl₂ / Heating

4: 100 percent / TFA; Et₃SiH / H₂O / 1 h / 20 °C

With piperidine; triethylsilane; Grubbs catalyst first generation; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm0203635

Reference yield:

: 495403-73-1
{1-[(S)-2-Carbamoyl-1-((S)-2-naphthalen-1-ylmethyl-pent-4-enylcarbamoyl)-ethylcarbamoyl]-1-methyl-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

: 495404-53-0
tert-butyl 2-[(1S,7S,11S,15S)-3,6,9-triaza-15-(4-{[bis(tert-butoxy)phosphono]methyl}phenyl)-7-(carbamoylmethyl)-4,4-dimethyl-11-(naphthylmethyl)-2,5,8-trioxocyclopentadec-13-enyl]acetate

Guidance literature:: Multi-step reaction with 3 steps

1: piperidine / acetonitrile / 2 h / 20 °C

2: 75 percent / HOAt; EDCI / dimethylformamide / 20 °C

3: 83 percent / (PCy₃)2Cl₂Ru=CHPh / CH₂Cl₂ / Heating

With piperidine; Grubbs catalyst first generation; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm0203635