1-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(5-((2-((3-methoxy-5-(2-morpholinoethoxy)phenyl)amino)pyrimidin-4-yl)oxy)quinolin-8-yl)urea

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Chemical Name:1-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(5-((2-((3-methoxy-5-(2-morpholinoethoxy)phenyl)amino)pyrimidin-4-yl)oxy)quinolin-8-yl)urea
CAS No.:1610449-50-7
Molecular Formula:C₄₀H₄₃N₉O₅
Molecular Weight:729.839
Hs Code.:

Synonyms:1-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(5-((2-((3-methoxy-5-(2-morpholinoethoxy)phenyl)amino)pyrimidin-4-yl)oxy)quinolin-8-yl)urea

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Chemical Property of 1-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(5-((2-((3-methoxy-5-(2-morpholinoethoxy)phenyl)amino)pyrimidin-4-yl)oxy)quinolin-8-yl)urea

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Technology Process of 1-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(5-((2-((3-methoxy-5-(2-morpholinoethoxy)phenyl)amino)pyrimidin-4-yl)oxy)quinolin-8-yl)urea

There total 7 articles about 1-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(5-((2-((3-methoxy-5-(2-morpholinoethoxy)phenyl)amino)pyrimidin-4-yl)oxy)quinolin-8-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 725237-20-7
3-methoxy-5-(2-morpholinoethoxy)aniline

: 1610450-23-1
1-(5-((2-chloropyrimidin-4-yl)oxy)quinolin-8-yl)-3-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)urea

: 1610449-50-7
1-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(5-((2-((3-methoxy-5-(2-morpholinoethoxy)phenyl)amino)pyrimidin-4-yl)oxy)quinolin-8-yl)urea

Guidance literature:: With toluene-4-sulfonic acid; In tetrahydrofuran; N,N-dimethyl-formamide; at 70 ℃;

Reference yield:

: 1573339-05-5
5-((2-chloropyrimidin-4-yl)oxy)-8-nitroquinoline

: 1610449-50-7
1-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(5-((2-((3-methoxy-5-(2-morpholinoethoxy)phenyl)amino)pyrimidin-4-yl)oxy)quinolin-8-yl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: iron; ammonium chloride / water; isopropyl alcohol / 16 h / Reflux

2: triethylamine / Isopropyl acetate / 3 h / 70 °C

3: toluene-4-sulfonic acid / tetrahydrofuran; N,N-dimethyl-formamide / 70 °C

With iron; ammonium chloride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; Isopropyl acetate; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 129717-35-7
5-hydroxy-8-nitroquinoline

: 1610449-50-7
1-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(5-((2-((3-methoxy-5-(2-morpholinoethoxy)phenyl)amino)pyrimidin-4-yl)oxy)quinolin-8-yl)urea

Guidance literature:: Multi-step reaction with 4 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 6 h / 0 - 60 °C

2: iron; ammonium chloride / water; isopropyl alcohol / 16 h / Reflux

3: triethylamine / Isopropyl acetate / 3 h / 70 °C

4: toluene-4-sulfonic acid / tetrahydrofuran; N,N-dimethyl-formamide / 70 °C

With iron; ammonium chloride; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; Isopropyl acetate; water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;