4-(5-fluoro-1H-indol-3-yl)-N-(4-{4-[(1-methyl-1H-pyrazol-4-yl)sulfonyl]piperazin-1-yl}phenyl)pyrimidin-2-amine trifluoroacetic acid

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Chemical Name:4-(5-fluoro-1H-indol-3-yl)-N-(4-{4-[(1-methyl-1H-pyrazol-4-yl)sulfonyl]piperazin-1-yl}phenyl)pyrimidin-2-amine trifluoroacetic acid
CAS No.:1000183-36-7
Molecular Formula:C₂HF₃O₂*C₂₆H₂₅FN₈O₂S
Molecular Weight:646.625
Hs Code.:

Synonyms:4-(5-fluoro-1H-indol-3-yl)-N-(4-{4-[(1-methyl-1H-pyrazol-4-yl)sulfonyl]piperazin-1-yl}phenyl)pyrimidin-2-amine trifluoroacetic acid

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Chemical Property of 4-(5-fluoro-1H-indol-3-yl)-N-(4-{4-[(1-methyl-1H-pyrazol-4-yl)sulfonyl]piperazin-1-yl}phenyl)pyrimidin-2-amine trifluoroacetic acid

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Technology Process of 4-(5-fluoro-1H-indol-3-yl)-N-(4-{4-[(1-methyl-1H-pyrazol-4-yl)sulfonyl]piperazin-1-yl}phenyl)pyrimidin-2-amine trifluoroacetic acid

There total 8 articles about 4-(5-fluoro-1H-indol-3-yl)-N-(4-{4-[(1-methyl-1H-pyrazol-4-yl)sulfonyl]piperazin-1-yl}phenyl)pyrimidin-2-amine trifluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1000183-35-6
4-(5-fluoro-1H-indol-3-yl)-N-(4-{4-[(1-methyl-1H-pyrazol-4-yl)sulfonyl]piperazin-1-yl}phenyl)pyrimidin-2-amine

: 76-05-1
trifluoroacetic acid

: 1000183-36-7
4-(5-fluoro-1H-indol-3-yl)-N-(4-{4-[(1-methyl-1H-pyrazol-4-yl)sulfonyl]piperazin-1-yl}phenyl)pyrimidin-2-amine trifluoroacetic acid

Guidance literature:: In water; acetonitrile;

Reference yield:

: 399-52-0
5-fluoro-1H-indole

: 1000183-36-7
4-(5-fluoro-1H-indol-3-yl)-N-(4-{4-[(1-methyl-1H-pyrazol-4-yl)sulfonyl]piperazin-1-yl}phenyl)pyrimidin-2-amine trifluoroacetic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: dmap; triethylamine / dichloromethane / 12 h

2.1: N-Bromosuccinimide / dichloromethane / 12 h

3.1: Triisopropyl borate; sec.-butyllithium / tetrahydrofuran; cyclohexane / 1 h / -78 °C

3.2: 2.5 h / 20 °C

3.3: 0.5 h

4.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2 h / 80 °C

5.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,4-dioxane / 12 h / 100 °C

6.1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

7.1: triethylamine / dmap / N,N-dimethyl-formamide / 12 h

8.1: water; acetonitrile

With dmap; N-Bromosuccinimide; Triisopropyl borate; sec.-butyllithium; sodium hydrogencarbonate; caesium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; cyclohexane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1000183-46-9
3-bromo-5-fluoro-1-Boc-1H-indole

: 1000183-36-7
4-(5-fluoro-1H-indol-3-yl)-N-(4-{4-[(1-methyl-1H-pyrazol-4-yl)sulfonyl]piperazin-1-yl}phenyl)pyrimidin-2-amine trifluoroacetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: Triisopropyl borate; sec.-butyllithium / tetrahydrofuran; cyclohexane / 1 h / -78 °C

1.2: 2.5 h / 20 °C

1.3: 0.5 h

2.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2 h / 80 °C

3.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,4-dioxane / 12 h / 100 °C

4.1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

5.1: triethylamine / dmap / N,N-dimethyl-formamide / 12 h

6.1: water; acetonitrile

With Triisopropyl borate; sec.-butyllithium; sodium hydrogencarbonate; caesium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; cyclohexane; water; N,N-dimethyl-formamide; acetonitrile;