(3S)-3-[N-(Ac-Asp(O-tBu)-D-Glu(O-tBu)-Leu-Ile-Cha)-amino]-4-hydroxy-10-methyl-5-undecene

Base Information

Chemical Name:(3S)-3-[N-(Ac-Asp(O-tBu)-D-Glu(O-tBu)-Leu-Ile-Cha)-amino]-4-hydroxy-10-methyl-5-undecene
CAS No.:622841-16-1
Molecular Formula:C₅₂H₉₂N₆O₁₁
Molecular Weight:977.336
Hs Code.:

Synonyms:(3S)-3-[N-(Ac-Asp(O-tBu)-D-Glu(O-tBu)-Leu-Ile-Cha)-amino]-4-hydroxy-10-methyl-5-undecene

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Chemical Property of (3S)-3-[N-(Ac-Asp(O-tBu)-D-Glu(O-tBu)-Leu-Ile-Cha)-amino]-4-hydroxy-10-methyl-5-undecene

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Technology Process of (3S)-3-[N-(Ac-Asp(O-tBu)-D-Glu(O-tBu)-Leu-Ile-Cha)-amino]-4-hydroxy-10-methyl-5-undecene

There total 7 articles about (3S)-3-[N-(Ac-Asp(O-tBu)-D-Glu(O-tBu)-Leu-Ile-Cha)-amino]-4-hydroxy-10-methyl-5-undecene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1860-39-5
5-methylhexanal

: 622841-16-1
(3S)-3-[N-(Ac-Asp(O-tBu)-D-Glu(O-tBu)-Leu-Ile-Cha)-amino]-4-hydroxy-10-methyl-5-undecene

Guidance literature:: Multi-step reaction with 4 steps

1: 24 percent / K₂CO₃ / ethanol / 16 h

2: 74 percent / NaBH₄ / methanol / 2.5 h / 0 °C

3: TMSOTf; 2,6-lutidine / CH₂Cl₂ / 6 h

4: 200 mg / PyBOP; DIPEA / CH₂Cl₂ / 16 h

With 2,6-dimethylpyridine; sodium tetrahydroborate; trimethylsilyl trifluoromethanesulfonate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane; 1: Horner-Wadsworth-Emmons reaction;
DOI:10.1016/S0968-0896(03)00190-1

Reference yield:

: 71989-23-6,251316-98-0
Fmoc-Ile-OH

: 622841-16-1
(3S)-3-[N-(Ac-Asp(O-tBu)-D-Glu(O-tBu)-Leu-Ile-Cha)-amino]-4-hydroxy-10-methyl-5-undecene

Guidance literature:: Multi-step reaction with 2 steps

1: 200 mg / PyBOP; DIPEA / CH₂Cl₂ / 16 h

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/S0968-0896(03)00190-1

Reference yield:

: 135673-97-1
(S)-3-cyclohexyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionic acid

: 622841-16-1
(3S)-3-[N-(Ac-Asp(O-tBu)-D-Glu(O-tBu)-Leu-Ile-Cha)-amino]-4-hydroxy-10-methyl-5-undecene

Guidance literature:: Multi-step reaction with 2 steps

1: 200 mg / PyBOP; DIPEA / CH₂Cl₂ / 16 h

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/S0968-0896(03)00190-1