4-[5'-[5''-(4'''-(carboxymethylene)piperazin-1'''-yl)-1H-benzimidazol-2''-yl]-3H-benzimidazol-2'-yl]phenol

Base Information

Chemical Name:4-[5'-[5''-(4'''-(carboxymethylene)piperazin-1'''-yl)-1H-benzimidazol-2''-yl]-3H-benzimidazol-2'-yl]phenol
CAS No.:188247-21-4
Molecular Formula:C₂₆H₂₄N₆O₃
Molecular Weight:468.515
Hs Code.:

Synonyms:4-[5'-[5''-(4'''-(carboxymethylene)piperazin-1'''-yl)-1H-benzimidazol-2''-yl]-3H-benzimidazol-2'-yl]phenol

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Chemical Property of 4-[5'-[5''-(4'''-(carboxymethylene)piperazin-1'''-yl)-1H-benzimidazol-2''-yl]-3H-benzimidazol-2'-yl]phenol

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Technology Process of 4-[5'-[5''-(4'''-(carboxymethylene)piperazin-1'''-yl)-1H-benzimidazol-2''-yl]-3H-benzimidazol-2'-yl]phenol

There total 6 articles about 4-[5'-[5''-(4'''-(carboxymethylene)piperazin-1'''-yl)-1H-benzimidazol-2''-yl]-3H-benzimidazol-2'-yl]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 510720-16-8
4-[5'-[5'-(4''-(ethoxycarbonylmethylene)piperazin-1''-yl)-1H-benzmidazol-2'-yl]-1H-benzimidazol-2'-yl]phenol

: 188247-21-4
4-[5'-[5''-(4'''-(carboxymethylene)piperazin-1'''-yl)-1H-benzimidazol-2''-yl]-3H-benzimidazol-2'-yl]phenol

Guidance literature:: With hydrogenchloride; water; for 2.5h; Heating / reflux;

Reference yield:

: 334685-22-2
ethyl 2-(4-{2-[2-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-1H-benzimidazol-6-yl}piperazin-1-yl)acetate

: 188247-21-4
{4-[2'-(4-hydroxy-phenyl)-3H,3'H-[2,5']bibenzoimidazolyl-5-yl]-piperazin-1-yl}-acetic acid

Guidance literature:: With hydrogen bromide; In water; at 130 ℃; for 1h;
DOI:10.1002/1522-2675(20000906)83:9<2197::AID-HLCA2197>3.0.CO;2-N

Reference yield:

: 1635-61-6
5-chloro-2-nitroaniline

: 188247-21-4
{4-[2'-(4-hydroxy-phenyl)-3H,3'H-[2,5']bibenzoimidazolyl-5-yl]-piperazin-1-yl}-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: K₂CO₃ / dimethylformamide / 8 h / 130 °C

2: EtN(i-Pr)2 / dimethylformamide / 20 °C

3: H₂ / 10 percent Pd-C / ethyl acetate / 1 h

4: 15 mg / nitrobenzene / 19 h / 150 °C

5: 48 percent HBr / H₂O / 1 h / 130 °C

With hydrogen bromide; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In water; ethyl acetate; nitrobenzene; N,N-dimethyl-formamide; 1: Substitution / 2: Substitution / 3: Reduction / 4: Substitution / 5: Hydrolysis;
DOI:10.1002/1522-2675(20000906)83:9<2197::AID-HLCA2197>3.0.CO;2-N