11-[2'-(1-azido-2-benzyloxy-ethyl)-6,4',6'-trimethoxy-biphenyl-3-yl]-8-tert-butoxycarbonylamino-5,15-dihydroxy-4-methoxy-9,12-dioxo-2-oxa-10,13-diaza-tricyclo[14.2.2.1^3,7]heneicosa-1⁽¹⁹⁾,3⁽²¹⁾,4,6,16⁽²⁰⁾,17-hexaene-14-carboxylic acid ethyl ester

Base Information

• Chemical Name: 11-[2'-(1-azido-2-benzyloxy-ethyl)-6,4',6'-trimethoxy-biphenyl-3-yl]-8-tert-butoxycarbonylamino-5,15-dihydroxy-4-methoxy-9,12-dioxo-2-oxa-10,13-diaza-tricyclo[14.2.2.1^3,7]heneicosa-1⁽¹⁹⁾,3⁽²¹⁾,4,6,16⁽²⁰⁾,17-hexaene-14-carboxylic acid ethyl ester
• CAS No.: 851912-49-7
• Molecular Formula: C₅₁H₅₆N₆O₁₄
• Molecular Weight: 977.037

Synonyms:11-[2'-(1-azido-2-benzyloxy-ethyl)-6,4',6'-trimethoxy-biphenyl-3-yl]-8-tert-butoxycarbonylamino-5,15-dihydroxy-4-methoxy-9,12-dioxo-2-oxa-10,13-diaza-tricyclo[14.2.2.1^3,7]heneicosa-1⁽¹⁹⁾,3⁽²¹⁾,4,6,16⁽²⁰⁾,17-hexaene-14-carboxylic acid ethyl ester

Chemical Property of 11-[2'-(1-azido-2-benzyloxy-ethyl)-6,4',6'-trimethoxy-biphenyl-3-yl]-8-tert-butoxycarbonylamino-5,15-dihydroxy-4-methoxy-9,12-dioxo-2-oxa-10,13-diaza-tricyclo[14.2.2.1^3,7]heneicosa-1⁽¹⁹⁾,3⁽²¹⁾,4,6,16⁽²⁰⁾,17-hexaene-14-carboxylic acid ethyl ester

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Technology Process of 11-[2'-(1-azido-2-benzyloxy-ethyl)-6,4',6'-trimethoxy-biphenyl-3-yl]-8-tert-butoxycarbonylamino-5,15-dihydroxy-4-methoxy-9,12-dioxo-2-oxa-10,13-diaza-tricyclo[14.2.2.1^3,7]heneicosa-1⁽¹⁹⁾,3⁽²¹⁾,4,6,16⁽²⁰⁾,17-hexaene-14-carboxylic acid ethyl ester

There total 1 articles about 11-[2'-(1-azido-2-benzyloxy-ethyl)-6,4',6'-trimethoxy-biphenyl-3-yl]-8-tert-butoxycarbonylamino-5,15-dihydroxy-4-methoxy-9,12-dioxo-2-oxa-10,13-diaza-tricyclo[14.2.2.1^3,7]heneicosa-1⁽¹⁹⁾,3⁽²¹⁾,4,6,16⁽²⁰⁾,17-hexaene-14-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

C57H70N6O14Si (851912-48-6) → 11-[2'-(1-azido-2-benzyloxy-ethyl)-6,4',6'-trimethoxy-biphenyl-3-yl]-8-tert-butoxycarbonylamino-5,15-dihydroxy-4-methoxy-9,12-dioxo-2-oxa-10,13-diaza-tricyclo[14.2.2.13,7]heneicosa-1(19),3(21),4,6,16(20),17-hexaene-14-carboxylic acid ethyl ester (851912-49-7)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at -15 - 0 ℃; for 5h;

DOI:10.1016/j.tetlet.2005.02.108

Reference yield: 88.0%

11-[2'-(1-azido-2-benzyloxy-ethyl)-6,4',6'-trimethoxy-biphenyl-3-yl]-8-tert-butoxycarbonylamino-5,15-dihydroxy-4-methoxy-9,12-dioxo-2-oxa-10,13-diaza-tricyclo[14.2.2.13,7]heneicosa-1(19),3(21),4,6,16(20),17-hexaene-14-carboxylic acid ethyl ester (851912-49-7) → 11-[2'-(1-amino-2-benzyloxy-ethyl)-6,4',6'-trimethoxy-biphenyl-3-yl]-8-tert-butoxycarbonylamino-5,15-dihydroxy-4-methoxy-9,12-dioxo-2-oxa-10,13-diaza-tricyclo[14.2.2.13,7]heneicosa-1(19),3(21),4,6,16(20),17-hexaene-14-carboxylic acid ethyl ester (851912-50-0)

Guidance literature:

With triethylphosphine; In water; acetonitrile; at 20 ℃; for 21h;

DOI:10.1016/j.tetlet.2005.02.108

Reference yield:

11-[2'-(1-azido-2-benzyloxy-ethyl)-6,4',6'-trimethoxy-biphenyl-3-yl]-8-tert-butoxycarbonylamino-5,15-dihydroxy-4-methoxy-9,12-dioxo-2-oxa-10,13-diaza-tricyclo[14.2.2.13,7]heneicosa-1(19),3(21),4,6,16(20),17-hexaene-14-carboxylic acid ethyl ester (851912-49-7) → C44H44N4O11

Guidance literature:

Multi-step reaction with 4 steps

1: 88 percent / Et₃P / acetonitrile; H₂O / 21 h / 20 °C

2: LiOH / tetrahydrofuran; H₂O / 0.17 h / 0 °C

3: pentafluorophenyl diphenylphosphinate; iPr₂NEt / dimethylformamide / 12 h / 0 °C

4: 85 percent / HCO₂H / CHCl₃ / 7 h / 20 °C

With lithium hydroxide; formic acid; pentafluorophenyl diphenyl-phosphinate; N-ethyl-N,N-diisopropylamine; triethylphosphine; In tetrahydrofuran; chloroform; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.tetlet.2005.02.108

upstream raw materials:

C₅₇H₇₀N₆O₁₄Si

Downstream raw materials:

11-[2'-(1-amino-2-benzyloxy-ethyl)-6,4',6'-trimethoxy-biphenyl-3-yl]-8-tert-butoxycarbonylamino-5,15-dihydroxy-4-methoxy-9,12-dioxo-2-oxa-10,13-diaza-tricyclo[14.2.2.1^3,7]heneicosa-1⁽¹⁹⁾,3⁽²¹⁾,4,6,16⁽²⁰⁾,17-hexaene-14-carboxylic acid ethyl ester

C₄₉H₅₂N₄O₁₃

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